Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

MNX1 - motor neuron and pancreas homeobox 1

Function

Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity).

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
3110	ENSG00000130675	MNX1	P50219

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000130675 as Regulator

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-01632	MCM6	down-regulates	MNX1	represses	R-2262	4	1	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-01720	MDC1	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01731	ARHGAP5	down-regulates	MNX1	represses	R-2260	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01732	ARHGAP5	down-regulates	MNX1	activates	R-2261	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01838	TMPRSS15	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01902	CYP4F8	down-regulates	MNX1	represses	R-2260	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01903	CYP4F8	down-regulates	MNX1	activates	R-2261	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-02799	DHX30	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-02897	SRRM2	down-regulates	MNX1	represses	R-2260	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-02898	SRRM2	down-regulates	MNX1	activates	R-2261	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-03225	PTPRM	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-03272	HRNR	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04297	RBPJL	down-regulates	MNX1	represses	R-2262	4	1	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-05316	PCSK6	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05602	BCLAF1	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06564	STAG2	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06591	RLTPR	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07339	NOD2	down-regulates	MNX1	represses	R-2260	4	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07340	NOD2	down-regulates	MNX1	represses	R-2262	4	3	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-07341	NOD2	down-regulates	MNX1	activates	R-2261	4	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07724	TRPM2	down-regulates	MNX1	represses	R-2262	4	2	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-07725	TRPM2	down-regulates	MNX1	activates	R-2261	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07878	FAM83B	down-regulates	MNX1	represses	R-2262	4	2	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-07879	FAM83B	down-regulates	MNX1	activates	R-2261	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-08182	CAD	down-regulates	MNX1	activates	R-2261	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-08570	TREML2	up-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-09228	TANC2	down-regulates	MNX1	represses	R-2262	4	1	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-09632	OR9G9	down-regulates	MNX1	represses	R-2260	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-09633	OR9G9	down-regulates	MNX1	represses	R-2262	4	2	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-09917	NAALADL2	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10012	ALB	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10556	LRBA	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-12516	LAMB3	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14637	C1orf177	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15118	KCNQ5	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15441	DSE	down-regulates	MNX1	represses	R-2262	4	2	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-15687	DCHS2	down-regulates	MNX1	represses	R-2260	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15688	DCHS2	down-regulates	MNX1	activates	R-2261	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15811	GRM3	down-regulates	MNX1	represses	R-2262	4	1	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-16477	SUSD5	down-regulates	MNX1	represses	R-2260	4	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-16478	SUSD5	down-regulates	MNX1	represses	R-2262	4	3	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-16479	SUSD5	down-regulates	MNX1	activates	R-2261	4	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-16580	RBM19	up-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-16679	DNAJC11	down-regulates	MNX1	represses	R-2262	4	2	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-17043	EPPK1	down-regulates	MNX1	represses	R-2260	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17044	EPPK1	down-regulates	MNX1	activates	R-2261	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17058	OR8J3	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17254	MAP3K7	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17551	CNTNAP3	down-regulates	MNX1	represses	R-2262	4	1	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-18315	MEGF8	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18497	LAMA1	down-regulates	MNX1	represses	R-2260	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18498	LAMA1	down-regulates	MNX1	activates	R-2261	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19082	COL4A4	down-regulates	MNX1	represses	R-2260	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19083	COL4A4	down-regulates	MNX1	represses	R-2262	4	2	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-19783	BVES	down-regulates	MNX1	represses	R-2262	4	1	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-20315	FREM1	down-regulates	MNX1	represses	R-2260	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20316	FREM1	down-regulates	MNX1	activates	R-2261	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20602	ADCY1	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20686	CYP4B1	down-regulates	MNX1	represses	R-2262	4	1	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-20736	ALPK1	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-21076	KRTAP4-7	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-21404	GRIK3	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22083	SSTR4	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22807	IDH1	up-regulates	MNX1	represses	R-2260	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22808	IDH1	up-regulates	MNX1	represses	R-2262	4	2	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-23359	DOCK2	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23978	TP53	up-regulates	MNX1	represses	R-2260	4	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23979	TP53	up-regulates	MNX1	represses	R-2262	4	3	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-23980	TP53	up-regulates	MNX1	activates	R-2261	4	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24263	SFRS15	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24351	SMCHD1	down-regulates	MNX1	represses	R-2262	4	2	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-24739	RABGEF1	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24780	PCDH11Y	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-25204	ZNF534	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26236	ADAMTS12	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26495	EGFR	down-regulates	MNX1	represses	R-2262	4	1	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-26602	NAALADL1	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26877	VAV1	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27262	MAP3K9	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27269	PUM1	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27343	CHD5	down-regulates	MNX1	represses	R-2262	4	1	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-27812	CSMD3	down-regulates	MNX1	activates	R-2261	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-28987	ZFC3H1	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-29079	DNAH3	down-regulates	MNX1	represses	R-2260	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-29431	EPHA8	down-regulates	MNX1	represses	R-2262	4	1	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN

MNX1 - motor neuron and pancreas homeobox 1

Function

Causal Mechanistic Flows with ENSG00000130675 as Regulator

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