Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
HOXD9 - homeobox D9
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 3235 | ENSG00000128709 | HOXD9 | P28356 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000128709 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-04851 | NEFM | down-regulates | HOXD9 | represses | R-1671 | 5 | 2 | Drugs (1) |
| CMF-15799 | GRM3 | down-regulates | HOXD9 | represses | R-1671 | 5 | 2 | Drugs (1) |
| CMF-16227 | USP11 | up-regulates | HOXD9 | represses | R-1671 | 5 | 2 | Drugs (1) |
| CMF-21359 | GRIK3 | down-regulates | HOXD9 | represses | R-1671 | 5 | 2 | Drugs (1) |
| CMF-24492 | SEMA3C | up-regulates | HOXD9 | represses | R-1671 | 5 | 2 | Drugs (1) |
| CMF-29789 | SLC5A7 | down-regulates | HOXD9 | represses | R-1671 | 5 | 1 | Drugs (1) |