Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

SOX4 - SRY-box transcription factor 4

Function

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311).

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
6659 ENSG00000124766 SOX4 Q06945

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000124766 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-04191RBPJLdown-regulatesSOX4repressesR-2053153Drugs (9)
CMF-04516LAMC3up-regulatesSOX4repressesR-2053155Drugs (9)
CMF-04517LAMC3up-regulatesSOX4repressesR-2056155Drugs (23)
CMF-04893ABCC5up-regulatesSOX4repressesR-2053153Drugs (9)
CMF-04894ABCC5up-regulatesSOX4repressesR-2056153Drugs (23)
CMF-06743ATRXup-regulatesSOX4repressesR-2053159Drugs (9)
CMF-06746ATRXup-regulatesSOX4repressesR-2056159Drugs (23)
CMF-09257RP1up-regulatesSOX4repressesR-2053154Drugs (9)
CMF-09258RP1up-regulatesSOX4repressesR-2056154Drugs (23)
CMF-09593OR9G9down-regulatesSOX4repressesR-2056154Drugs (23)
CMF-10500LRBAdown-regulatesSOX4repressesR-2056154Drugs (23)
CMF-11570MYH15up-regulatesSOX4repressesR-2053152Drugs (9)
CMF-19244NF1down-regulatesSOX4repressesR-2053155Drugs (9)
CMF-19245NF1down-regulatesSOX4repressesR-2056155Drugs (23)
CMF-22066SSTR4down-regulatesSOX4repressesR-2056151Drugs (23)
CMF-22359IDH1up-regulatesSOX4repressesR-20531510Drugs (9)
CMF-22362IDH1up-regulatesSOX4repressesR-20561510Drugs (23)
CMF-23638TP53up-regulatesSOX4repressesR-2056157Drugs (23)
CMF-25909MMP13down-regulatesSOX4repressesR-2056152Drugs (23)
CMF-30254RAB3GAP2down-regulatesSOX4repressesR-2056152Drugs (23)