Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
EGR1 - early growth response 1
Function
Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 1958 | ENSG00000120738 | EGR1 | P18146 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000120738 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00571 | HMCN1 | up-regulates | EGR1 | activates | R-993 | 20 | 10 | Drugs (4) |
| CMF-00573 | HMCN1 | up-regulates | EGR1 | activates | R-991 | 20 | 10 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB |
| CMF-00575 | HMCN1 | up-regulates | EGR1 | activates | R-1006 | 20 | 10 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-00578 | HMCN1 | up-regulates | EGR1 | activates | R-998 | 20 | 10 | Drugs (5) |
| CMF-00579 | HMCN1 | up-regulates | EGR1 | activates | R-996 | 20 | 10 | Drugs (2) |
| CMF-00580 | HMCN1 | up-regulates | EGR1 | activates | R-1005 | 20 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01802 | TMPRSS15 | up-regulates | EGR1 | activates | R-995 | 20 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-01804 | TMPRSS15 | up-regulates | EGR1 | activates | R-996 | 20 | 5 | Drugs (2) |
| CMF-01805 | TMPRSS15 | up-regulates | EGR1 | activates | R-1003 | 20 | 5 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-02693 | UBE3C | down-regulates | EGR1 | activates | R-998 | 20 | 1 | Drugs (5) |
| CMF-02736 | TMEM229B | down-regulates | EGR1 | activates | R-1003 | 20 | 1 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-05370 | KDELC2 | up-regulates | EGR1 | activates | R-993 | 20 | 2 | Drugs (4) |
| CMF-06832 | ATRX | down-regulates | EGR1 | activates | R-993 | 20 | 12 | Drugs (4) |
| CMF-06835 | ATRX | down-regulates | EGR1 | activates | R-995 | 20 | 12 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-06837 | ATRX | down-regulates | EGR1 | activates | R-991 | 20 | 12 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB |
| CMF-06839 | ATRX | down-regulates | EGR1 | activates | R-1006 | 20 | 12 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-06840 | ATRX | down-regulates | EGR1 | activates | R-998 | 20 | 12 | Drugs (5) |
| CMF-06841 | ATRX | down-regulates | EGR1 | activates | R-996 | 20 | 12 | Drugs (2) |
| CMF-06842 | ATRX | down-regulates | EGR1 | activates | R-1003 | 20 | 12 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-06843 | ATRX | down-regulates | EGR1 | activates | R-1005 | 20 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08591 | FOXR2 | down-regulates | EGR1 | activates | R-993 | 20 | 5 | Drugs (4) |
| CMF-08593 | FOXR2 | down-regulates | EGR1 | activates | R-998 | 20 | 5 | Drugs (5) |
| CMF-08594 | FOXR2 | down-regulates | EGR1 | activates | R-996 | 20 | 5 | Drugs (2) |
| CMF-08595 | FOXR2 | down-regulates | EGR1 | activates | R-1005 | 20 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09421 | ZIC4 | up-regulates | EGR1 | activates | R-993 | 20 | 3 | Drugs (4) |
| CMF-10514 | LRBA | up-regulates | EGR1 | activates | R-995 | 20 | 7 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-10516 | LRBA | up-regulates | EGR1 | activates | R-996 | 20 | 7 | Drugs (2) |
| CMF-10518 | LRBA | up-regulates | EGR1 | activates | R-1005 | 20 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11171 | DGKD | down-regulates | EGR1 | activates | R-995 | 20 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-12491 | LAMB3 | up-regulates | EGR1 | activates | R-993 | 20 | 2 | Drugs (4) |
| CMF-13786 | ADAMTS8 | down-regulates | EGR1 | activates | R-996 | 20 | 3 | Drugs (2) |
| CMF-14482 | PRKCD | down-regulates | EGR1 | activates | R-991 | 20 | 4 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB |
| CMF-14483 | PRKCD | down-regulates | EGR1 | activates | R-1006 | 20 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-14484 | PRKCD | down-regulates | EGR1 | activates | R-998 | 20 | 4 | Drugs (5) |
| CMF-14485 | PRKCD | down-regulates | EGR1 | activates | R-996 | 20 | 4 | Drugs (2) |
| CMF-14970 | XK | down-regulates | EGR1 | activates | R-1003 | 20 | 3 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-15268 | HCN1 | up-regulates | EGR1 | activates | R-1000 | 20 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15273 | HCN1 | up-regulates | EGR1 | activates | R-998 | 20 | 11 | Drugs (5) |
| CMF-15274 | HCN1 | up-regulates | EGR1 | activates | R-996 | 20 | 11 | Drugs (2) |
| CMF-15276 | HCN1 | up-regulates | EGR1 | activates | R-1005 | 20 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16911 | TIE1 | up-regulates | EGR1 | activates | R-993 | 20 | 1 | Drugs (4) |
| CMF-18208 | CDH19 | up-regulates | EGR1 | activates | R-993 | 20 | 4 | Drugs (4) |
| CMF-18209 | CDH19 | up-regulates | EGR1 | activates | R-1000 | 20 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18292 | MEGF8 | up-regulates | EGR1 | activates | R-991 | 20 | 2 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB |
| CMF-18293 | MEGF8 | up-regulates | EGR1 | activates | R-1005 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19302 | NF1 | up-regulates | EGR1 | activates | R-993 | 20 | 10 | Drugs (4) |
| CMF-19305 | NF1 | up-regulates | EGR1 | activates | R-995 | 20 | 10 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-19307 | NF1 | up-regulates | EGR1 | activates | R-991 | 20 | 10 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB |
| CMF-19309 | NF1 | up-regulates | EGR1 | activates | R-998 | 20 | 10 | Drugs (5) |
| CMF-19310 | NF1 | up-regulates | EGR1 | activates | R-996 | 20 | 10 | Drugs (2) |
| CMF-19311 | NF1 | up-regulates | EGR1 | activates | R-1005 | 20 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19925 | ACTL9 | up-regulates | EGR1 | activates | R-993 | 20 | 3 | Drugs (4) |
| CMF-19975 | GOLGB1 | up-regulates | EGR1 | activates | R-1003 | 20 | 2 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-21039 | KRTAP4-7 | up-regulates | EGR1 | activates | R-993 | 20 | 6 | Drugs (4) |
| CMF-21042 | KRTAP4-7 | up-regulates | EGR1 | activates | R-991 | 20 | 6 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB |
| CMF-21043 | KRTAP4-7 | up-regulates | EGR1 | activates | R-998 | 20 | 6 | Drugs (5) |
| CMF-21044 | KRTAP4-7 | up-regulates | EGR1 | activates | R-1005 | 20 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22478 | IDH1 | down-regulates | EGR1 | activates | R-993 | 20 | 13 | Drugs (4) |
| CMF-22481 | IDH1 | down-regulates | EGR1 | activates | R-995 | 20 | 13 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-22483 | IDH1 | down-regulates | EGR1 | activates | R-991 | 20 | 13 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB |
| CMF-22485 | IDH1 | down-regulates | EGR1 | activates | R-1006 | 20 | 13 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-22486 | IDH1 | down-regulates | EGR1 | activates | R-998 | 20 | 13 | Drugs (5) |
| CMF-22487 | IDH1 | down-regulates | EGR1 | activates | R-996 | 20 | 13 | Drugs (2) |
| CMF-22488 | IDH1 | down-regulates | EGR1 | activates | R-1003 | 20 | 13 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-22489 | IDH1 | down-regulates | EGR1 | activates | R-1005 | 20 | 13 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25963 | HDAC2 | down-regulates | EGR1 | activates | R-993 | 20 | 1 | Drugs (4) |
| CMF-26314 | CHGB | up-regulates | EGR1 | activates | R-998 | 20 | 4 | Drugs (5) |
| CMF-26315 | CHGB | up-regulates | EGR1 | activates | R-996 | 20 | 4 | Drugs (2) |
| CMF-26316 | CHGB | up-regulates | EGR1 | activates | R-1005 | 20 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27097 | NBAS | up-regulates | EGR1 | activates | R-1003 | 20 | 4 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-27211 | HTR3A | up-regulates | EGR1 | activates | R-1003 | 20 | 3 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-28213 | REPIN1 | up-regulates | EGR1 | activates | R-1005 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28759 | MLL4 | down-regulates | EGR1 | activates | R-993 | 20 | 4 | Drugs (4) |
| CMF-28761 | MLL4 | down-regulates | EGR1 | activates | R-998 | 20 | 4 | Drugs (5) |
| CMF-28762 | MLL4 | down-regulates | EGR1 | activates | R-996 | 20 | 4 | Drugs (2) |
| CMF-29625 | ESRRB | down-regulates | EGR1 | activates | R-1006 | 20 | 11 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-29627 | ESRRB | down-regulates | EGR1 | activates | R-996 | 20 | 11 | Drugs (2) |
| CMF-30185 | OR4K13 | down-regulates | EGR1 | activates | R-998 | 20 | 3 | Drugs (5) |
| CMF-30186 | OR4K13 | down-regulates | EGR1 | activates | R-1003 | 20 | 3 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-31315 | CLASS_I_PI3K_SIGNALING_EVENTS | up-regulates | EGR1 | activates | R-1006 | 20 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-31652 | PDGFR_BETA_SIGNALING_PATHWAY | up-regulates | EGR1 | activates | R-1006 | 20 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-31653 | PDGFR_BETA_SIGNALING_PATHWAY | up-regulates | EGR1 | activates | R-998 | 20 | 4 | Drugs (5) |