Summary of regulator annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
KLF12 - KLF transcription factor 12
Function
Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 11278 | ENSG00000118922 | KLF12 | Q9Y4X4 |
List of causal flows containing the regulator.
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000118922 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01274 | KRT37 | down-regulates | KLF12 | represses | R-3120 | 4 | 1 | Drugs (2) |
| CMF-07153 | ATRX | up-regulates | KLF12 | represses | R-3120 | 4 | 3 | Drugs (2) |
| CMF-20618 | ADCY1 | down-regulates | KLF12 | represses | R-3120 | 4 | 1 | Drugs (2) |
| CMF-21096 | KRTAP4-7 | down-regulates | KLF12 | represses | R-3120 | 4 | 2 | Drugs (2) |
| CMF-22944 | IDH1 | up-regulates | KLF12 | represses | R-3120 | 4 | 3 | Drugs (2) |
| CMF-24077 | TP53 | up-regulates | KLF12 | represses | R-3120 | 4 | 3 | Drugs (2) |
| CMF-27661 | ANKRD36 | down-regulates | KLF12 | represses | R-3120 | 4 | 2 | Drugs (2) |
| CMF-29732 | ESRRB | down-regulates | KLF12 | represses | R-3120 | 4 | 2 | Drugs (2) |