Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
DLX5 - distal-less homeobox 5
Function
Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 1749 | ENSG00000105880 | DLX5 | P56178 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000105880 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00673 | HMCN1 | down-regulates | DLX5 | represses | R-3309 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01830 | TMPRSS15 | down-regulates | DLX5 | represses | R-3309 | 6 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01970 | PCDH9 | down-regulates | DLX5 | represses | R-3309 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02644 | LBP | down-regulates | DLX5 | represses | R-3309 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02719 | ABCA5 | down-regulates | DLX5 | represses | R-3309 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02925 | OR5K4 | down-regulates | DLX5 | represses | R-3309 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05875 | ZNF813 | down-regulates | DLX5 | represses | R-3309 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08448 | COL17A1 | down-regulates | DLX5 | represses | R-3309 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14255 | APOBEC1 | down-regulates | DLX5 | represses | R-3309 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14360 | SIPA1L1 | down-regulates | DLX5 | represses | R-3309 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15548 | TAS2R41 | down-regulates | DLX5 | represses | R-3309 | 6 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16465 | SUSD5 | down-regulates | DLX5 | represses | R-3309 | 6 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18353 | SHB | down-regulates | DLX5 | represses | R-3309 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22081 | SSTR4 | down-regulates | DLX5 | represses | R-3309 | 6 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23529 | TNXB | down-regulates | DLX5 | represses | R-3309 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23956 | TP53 | up-regulates | DLX5 | represses | R-3309 | 6 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24261 | SFRS15 | down-regulates | DLX5 | represses | R-3309 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26492 | EGFR | down-regulates | DLX5 | represses | R-3309 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26645 | C5AR1 | down-regulates | DLX5 | represses | R-3309 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26870 | VAV1 | down-regulates | DLX5 | represses | R-3309 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29399 | PLB1 | down-regulates | DLX5 | represses | R-3309 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |