Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ERF - ETS2 repressor factor
Function
Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 2077 | ENSG00000105722 | ERF | P50548 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000105722 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00548 | HMCN1 | up-regulates | ERF | activates | R-3180 | 8 | 1 | Drugs (1) |
| CMF-09011 | NALCN | down-regulates | ERF | activates | R-3180 | 8 | 1 | Drugs (1) |
| CMF-10506 | LRBA | up-regulates | ERF | activates | R-3180 | 8 | 1 | Drugs (1) |
| CMF-22373 | IDH1 | down-regulates | ERF | activates | R-3180 | 8 | 1 | Drugs (1) |
| CMF-28758 | MLL4 | down-regulates | ERF | activates | R-3180 | 8 | 1 | Drugs (1) |