Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
E2F1 - E2F transcription factor 1
Function
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17704056, PubMed:17050006, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 1869 | ENSG00000101412 | E2F1 | Q01094 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000101412 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00500 | PIK3CA | down-regulates | E2F1 | activates | R-530 | 18 | 11 | Drugs (1) |
| CMF-02643 | LBP | down-regulates | E2F1 | activates | R-530 | 18 | 3 | Drugs (1) |
| CMF-04291 | RBPJL | down-regulates | E2F1 | activates | R-530 | 18 | 4 | Drugs (1) |
| CMF-04771 | ADAMTS20 | down-regulates | E2F1 | activates | R-530 | 18 | 4 | Drugs (1) |
| CMF-05434 | POTEE | down-regulates | E2F1 | activates | R-537 | 18 | 6 | Drugs (1) |
| CMF-05435 | POTEE | down-regulates | E2F1 | activates | R-530 | 18 | 6 | Drugs (1) |
| CMF-06182 | MDGA2 | down-regulates | E2F1 | activates | R-530 | 18 | 5 | Drugs (1) |
| CMF-06611 | CACNA1D | up-regulates | E2F1 | activates | R-537 | 18 | 2 | Drugs (1) |
| CMF-10205 | PAN3 | down-regulates | E2F1 | activates | R-537 | 18 | 4 | Drugs (1) |
| CMF-11367 | ZCCHC5 | down-regulates | E2F1 | activates | R-530 | 18 | 5 | Drugs (1) |
| CMF-12973 | SMC1A | down-regulates | E2F1 | activates | R-530 | 18 | 1 | Drugs (1) |
| CMF-16639 | KRT13 | down-regulates | E2F1 | activates | R-530 | 18 | 1 | Drugs (1) |
| CMF-16726 | PDE3A | up-regulates | E2F1 | activates | R-537 | 18 | 1 | Drugs (1) |
| CMF-17740 | PCDHB13 | up-regulates | E2F1 | activates | R-537 | 18 | 5 | Drugs (1) |
| CMF-20596 | ADCY1 | down-regulates | E2F1 | activates | R-530 | 18 | 4 | Drugs (1) |
| CMF-21452 | BOD1L | down-regulates | E2F1 | activates | R-530 | 18 | 6 | Drugs (1) |
| CMF-23923 | TP53 | up-regulates | E2F1 | activates | R-530 | 18 | 13 | Drugs (1) |
| CMF-25008 | IRS1 | down-regulates | E2F1 | activates | R-530 | 18 | 2 | Drugs (1) |
| CMF-31397 | CXCR3_MEDIATED_SIGNALING_EVENTS | down-regulates | E2F1 | activates | R-530 | 18 | 2 | Drugs (1) |
| CMF-31753 | PDGFR_ALPHA_SIGNALING_PATHWAY | down-regulates | E2F1 | activates | R-530 | 18 | 2 | Drugs (1) |
| CMF-32019 | FAS_SIGNALING_PATHWAY | down-regulates | E2F1 | activates | R-530 | 18 | 3 | Drugs (1) |
| CMF-32176 | VEGFR3_SIGNALING_IN_LYMPHATIC_ENDOTHELIUM | down-regulates | E2F1 | activates | R-530 | 18 | 5 | Drugs (1) |
| CMF-32191 | TRAIL_SIGNALING_PATHWAY | down-regulates | E2F1 | activates | R-530 | 18 | 4 | Drugs (1) |
| CMF-32470 | IL4_MEDIATED_SIGNALING_EVENTS | down-regulates | E2F1 | activates | R-530 | 18 | 6 | Drugs (1) |
| CMF-32702 | NONGENOTROPIC_ANDROGEN_SIGNALING | down-regulates | E2F1 | activates | R-530 | 18 | 4 | Drugs (1) |
| CMF-32893 | EPHA2_FORWARD_SIGNALING | down-regulates | E2F1 | activates | R-530 | 18 | 4 | Drugs (1) |
| CMF-33501 | NEPHRIN_NEPH1_SIGNALING_IN_THE_KIDNEY_PODOCYTE | down-regulates | E2F1 | activates | R-530 | 18 | 4 | Drugs (1) |