Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
TFAP2C - transcription factor AP-2 gamma
Function
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 7022 | ENSG00000087510 | TFAP2C | Q92754 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000087510 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01945 | PCDH9 | down-regulates | TFAP2C | activates | R-1346 | 15 | 2 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-02208 | PPL | down-regulates | TFAP2C | activates | R-1346 | 15 | 4 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-03138 | EEF1A1 | down-regulates | TFAP2C | represses | R-1340 | 15 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03838 | DSP | down-regulates | TFAP2C | represses | R-1340 | 15 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04376 | TYK2 | down-regulates | TFAP2C | activates | R-1346 | 15 | 3 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-05295 | PCSK6 | down-regulates | TFAP2C | represses | R-1340 | 15 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05889 | FAM71B | down-regulates | TFAP2C | activates | R-1346 | 15 | 1 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-06174 | MDGA2 | down-regulates | TFAP2C | represses | R-1340 | 15 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06912 | ATRX | down-regulates | TFAP2C | activates | R-1346 | 15 | 10 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-07414 | THOC2 | down-regulates | TFAP2C | represses | R-1340 | 15 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07713 | TRPM2 | down-regulates | TFAP2C | activates | R-1346 | 15 | 2 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-09122 | NLRP3 | down-regulates | TFAP2C | represses | R-1340 | 15 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09509 | DOCK11 | down-regulates | TFAP2C | represses | R-1340 | 15 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09620 | OR9G9 | down-regulates | TFAP2C | represses | R-1340 | 15 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12289 | GPR98 | down-regulates | TFAP2C | activates | R-1346 | 15 | 4 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-13273 | SULF2 | down-regulates | TFAP2C | activates | R-1346 | 15 | 3 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-14140 | CD1D | down-regulates | TFAP2C | represses | R-1340 | 15 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14976 | XK | down-regulates | TFAP2C | activates | R-1346 | 15 | 3 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-18581 | CNTNAP2 | down-regulates | TFAP2C | represses | R-1340 | 15 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22553 | IDH1 | down-regulates | TFAP2C | activates | R-1346 | 15 | 11 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-24622 | KCNC2 | down-regulates | TFAP2C | activates | R-1346 | 15 | 2 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-24763 | CHAT | down-regulates | TFAP2C | represses | R-1340 | 15 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26212 | CARD11 | down-regulates | TFAP2C | represses | R-1340 | 15 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26391 | MAGEB1 | down-regulates | TFAP2C | represses | R-1340 | 15 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26632 | C5AR1 | down-regulates | TFAP2C | represses | R-1340 | 15 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28290 | KRTAP4-8 | down-regulates | TFAP2C | activates | R-1346 | 15 | 2 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-30062 | FAM126B | down-regulates | TFAP2C | represses | R-1340 | 15 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |