Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
SP100 - SP100 nuclear antigen
Function
Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 6672 | ENSG00000067066 | SP100 | P23497 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000067066 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01350 | SDPR | up-regulates | SP100 | activates | R-2585 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01594 | MCM6 | up-regulates | SP100 | activates | R-2585 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06710 | ATRX | down-regulates | SP100 | activates | R-2585 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12661 | WDFY3 | up-regulates | SP100 | activates | R-2585 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20094 | TDRD9 | up-regulates | SP100 | activates | R-2585 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21564 | MUC17 | up-regulates | SP100 | activates | R-2585 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22320 | IDH1 | down-regulates | SP100 | activates | R-2585 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23605 | TP53 | down-regulates | SP100 | activates | R-2585 | 3 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25808 | CD163 | down-regulates | SP100 | activates | R-2585 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |