Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

RUNX3 - RUNX family transcription factor 3

Function

Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
864 ENSG00000020633 RUNX3 Q13761

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000020633 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-01137ZNF292down-regulatesRUNX3activatesR-194113Drugs (8)
CMF-01138ZNF292down-regulatesRUNX3activatesR-192113Drugs (56)
CMF-01991PCDH9down-regulatesRUNX3activatesR-197115Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090

CMF-01992PCDH9down-regulatesRUNX3activatesR-192115Drugs (56)
CMF-02697UBE3Cdown-regulatesRUNX3activatesR-197111Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090

CMF-02838MST1up-regulatesRUNX3activatesR-201111Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BIVATUZUMAB

CMF-04646CYP4F12down-regulatesRUNX3activatesR-196112Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-06056OTOAdown-regulatesRUNX3activatesR-196112Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-08131PLEKHG4Bdown-regulatesRUNX3activatesR-196112Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-09768MTF1down-regulatesRUNX3activatesR-196111Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-09972FBN1down-regulatesRUNX3activatesR-192111Drugs (56)
CMF-10864PKD1L2down-regulatesRUNX3activatesR-196112Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-11032BMP5down-regulatesRUNX3activatesR-196113Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-11147MYO18Adown-regulatesRUNX3activatesR-196112Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-11148MYO18Adown-regulatesRUNX3activatesR-192112Drugs (56)
CMF-13859ADAMTS8down-regulatesRUNX3activatesR-192112Drugs (56)
CMF-16760CPNE8up-regulatesRUNX3activatesR-192112Drugs (56)
CMF-18053PRPF40Bdown-regulatesRUNX3activatesR-194116Drugs (8)
CMF-18054PRPF40Bdown-regulatesRUNX3activatesR-192116Drugs (56)
CMF-19541NF1up-regulatesRUNX3activatesR-1961110Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-19546NF1up-regulatesRUNX3activatesR-2011110Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BIVATUZUMAB

CMF-19547NF1up-regulatesRUNX3activatesR-1941110Drugs (8)
CMF-19548NF1up-regulatesRUNX3activatesR-1971110Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090

CMF-19549NF1up-regulatesRUNX3activatesR-1921110Drugs (56)
CMF-20738ALPK1up-regulatesRUNX3activatesR-194111Drugs (8)
CMF-22175PDGFRAdown-regulatesRUNX3activatesR-197112Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090

CMF-22176PDGFRAdown-regulatesRUNX3activatesR-192112Drugs (56)
CMF-28669PCNXdown-regulatesRUNX3activatesR-194115Drugs (8)
CMF-28670PCNXdown-regulatesRUNX3activatesR-197115Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090

CMF-29129FOLH1Bdown-regulatesRUNX3activatesR-196111Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-30137PRKDCup-regulatesRUNX3activatesR-201111Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BIVATUZUMAB

CMF-30664SALL4down-regulatesRUNX3activatesR-196113Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-30666SALL4down-regulatesRUNX3activatesR-192113Drugs (56)
CMF-30712ABCA13down-regulatesRUNX3activatesR-197112Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090