Program – gbmMINER Portal

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Program – gbmMINER Portal

Program

Program Pr-88

Genes (52)

NSMAF, ATG4A, CTBS, SLC19A2, TMEM123, CRLF3, GK, TRAM1, LAPTM4A, STK17B, ATF1, TANK, NCK1, STEAP1, CFH, ZFX, SYPL1, BCAP29, C1GALT1, C18orf25, PIGB, TMED2, EDEM2, DNASE2, PRDX6, DCTD, FDX1, SLC38A6, PPIC, SDC2, TMEM50B, CASP8, TUBD1, ARL1, SLFN12, SDHD, TRIB3, FOXF1, WISP1, LRRC17, ITGA10, DKK2, LIPC, PPIB, PFDN4, GNG11, PMAIP1, EXT2, PLA2R1, RPS4X, SERTAD3, YIPF2

Regulons (17)

R-168, R-676, R-864, R-1114, R-1320, R-1420, R-1452, R-1458, R-1769, R-1958, R-2062, R-2445, R-2484, R-2490, R-2729, R-3025, R-3785

Regulons in program Pr-88

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-168	0.201338	7	2
R-676	0.274458	5	11
R-864	0.53738	7	4
R-1114	0.53738	7	5
R-1320	1.55532	6	7
R-1420	0.251716	6	9
R-1452	2.83505	10	2
R-1458	0.295748	7	2
R-1769	0.927833	5	11
R-1958	0.408819	6	4
R-2062	0.53738	7	6
R-2445	0.537417	8	10
R-2484	2.66135	9	6
R-2490	0.115082	7	6
R-2729	-0.336878	5	3
R-3025	0.437477	9	8
R-3785	0.132328	5	7

Genes in program Pr-88

EnsEMBL Id	Entrez Id	Preferred
ENSG00000035681	8439	NSMAF
ENSG00000101844	115201	ATG4A
ENSG00000117151	1486	CTBS
ENSG00000117479	10560	SLC19A2
ENSG00000152558	114908	TMEM123
ENSG00000176390	51379	CRLF3
ENSG00000198814	2710	GK
ENSG00000067167	23471	TRAM1
ENSG00000068697	9741	LAPTM4A
ENSG00000081320	9262	STK17B
ENSG00000123268	466	ATF1
ENSG00000136560	10010	TANK
ENSG00000158092	4690	NCK1
ENSG00000164647	26872	STEAP1
ENSG00000000971	3075	CFH
ENSG00000005889	7543	ZFX
ENSG00000008282	6856	SYPL1
ENSG00000075790	55973	BCAP29
ENSG00000106392	56913	C1GALT1
ENSG00000152242	147339	C18orf25
ENSG00000069943	9488	PIGB
ENSG00000086598	10959	TMED2
ENSG00000088298	55741	EDEM2
ENSG00000105612	1777	DNASE2
ENSG00000117592	9588	PRDX6
ENSG00000129187	1635	DCTD
ENSG00000137714	2230	FDX1
ENSG00000139974	145389	SLC38A6
ENSG00000168938	5480	PPIC
ENSG00000169439	6383	SDC2
ENSG00000263160	757	TMEM50B
ENSG00000064012	841	CASP8
ENSG00000108423	51174	TUBD1
ENSG00000120805	400	ARL1
ENSG00000172123	55106	SLFN12
ENSG00000204370	6392	SDHD
ENSG00000101255	57761	TRIB3
ENSG00000103241	2294	FOXF1
ENSG00000104415	8840	WISP1
ENSG00000128606	10234	LRRC17
ENSG00000143127	8515	ITGA10
ENSG00000155011	27123	DKK2
ENSG00000166035	3990	LIPC
ENSG00000166794	5479	PPIB
ENSG00000101132	5203	PFDN4
ENSG00000127920	2791	GNG11
ENSG00000141682	5366	PMAIP1
ENSG00000151348	2132	EXT2
ENSG00000153246	22925	PLA2R1
ENSG00000198034	6191	RPS4X
ENSG00000167565	29946	SERTAD3
ENSG00000130733	78992	YIPF2

Causal Mechanistic Flows with Program Pr-88

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-06797	ATRX	down-regulates	IRF7	activates	R-2484	21	19	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-09130	RSBN1L	up-regulates	IRF9	activates	R-1452	15	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-16403	SUSD5	up-regulates	IRF7	activates	R-2484	21	12	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18703	MPP7	down-regulates	IRF7	activates	R-2484	21	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20088	TDRD9	up-regulates	IRF9	activates	R-1452	15	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-21627	MUC17	up-regulates	IRF7	activates	R-2484	21	12	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22437	IDH1	down-regulates	IRF7	activates	R-2484	21	20	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-31452	SIGNALING_EVENTS_MEDIATED_BY_TCPTP	up-regulates	IRF7	activates	R-2484	21	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)

CMFlow summary not available

Enrichment summary not available