Pr-76
Genes (57)
AK1, EPHX2, MDFIC, RIC8A, PARN, ZMYND10, LRRC23, TOMM34, PIGV, SPA17, TAF6, CHCHD3, YKT6, C11orf63, CASC1, C7orf49, TTC12, RBKS, APITD1, IQCH, PDAP1, LRRC6, FOXJ1, DNALI1, TTC30A, DLEC1, TEKT2, TSNAXIP1, DNAH7, SPAG8, CETN2, ZNF214, TPPP3, C9orf116, NUP62CL, TCTN1, HYDIN, CD38, EXPH5, SLC37A1, GLB1L, C7orf25, IL13RA2, SHBG, MTTP, ACAA2, TXNRD1, KIAA0556, PHGDH, GALNT3, PLCD1, SLC7A2, TLE4, TTR, HSD17B3, CYP4F2, COL4A6Regulons (9)
R-1368, R-1814, R-2068, R-2298, R-2301, R-2979, R-3532, R-3701, R-3795Regulons in program Pr-76
| Regulon | Cox Hazard Ratio | # genes | # causal flows |
|---|---|---|---|
| R-1368 | 3.09309 | 5 | 11 |
| R-1814 | 2.92401 | 15 | 3 |
| R-2068 | 2.26291 | 9 | 4 |
| R-2298 | 2.1257 | 23 | 13 |
| R-2301 | 1.67489 | 8 | 12 |
| R-2979 | 2.63159 | 5 | 3 |
| R-3532 | 3.20873 | 5 | 2 |
| R-3701 | 1.03024 | 8 | 10 |
| R-3795 | 1.93932 | 6 | 16 |
Genes in program Pr-76
Causal Mechanistic Flows with Program Pr-76
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00470 | TP53 | down-regulates | RFX2 | activates | R-2298 | 6 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02018 | TCHH | down-regulates | BRF1 | represses | R-2979 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02037 | TCHH | down-regulates | SPDEF | represses | R-1814 | 17 | 1 | Drugs (1) |
| CMF-02318 | ERG | up-regulates | RFX2 | activates | R-2298 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03591 | RGS12 | down-regulates | RFX2 | activates | R-2298 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04441 | ADAM6 | down-regulates | SPDEF | represses | R-1814 | 17 | 1 | Drugs (1) |
| CMF-06981 | ATRX | down-regulates | RFX2 | activates | R-2298 | 6 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12127 | COL6A3 | up-regulates | RFX2 | activates | R-2298 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12134 | OR52M1 | down-regulates | BRF1 | represses | R-2979 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12637 | NUP205 | down-regulates | RFX5 | activates | R-2068 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13041 | PTPN3 | up-regulates | RFX2 | activates | R-2298 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13096 | CLYBL | up-regulates | RFX2 | activates | R-2298 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17504 | MECOM | down-regulates | RFX2 | activates | R-2298 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18406 | FANCM | down-regulates | RFX2 | activates | R-2298 | 6 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18980 | MLLT4 | up-regulates | RFX2 | activates | R-2298 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20779 | ASPM | down-regulates | SPDEF | represses | R-1814 | 17 | 1 | Drugs (1) |
| CMF-21821 | ITSN1 | up-regulates | BRF1 | represses | R-2979 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21865 | ITSN1 | up-regulates | CTCF | represses | R-3532 | 19 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ARSENIC TRIOXIDE, CINTREDEKIN BESUDOTOX, IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090, AUROTHIOGLUCOSE, MOTEXAFIN GADOLINIUM |
| CMF-22681 | IDH1 | down-regulates | RFX2 | activates | R-2298 | 6 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23025 | IDH1 | up-regulates | CTCF | represses | R-3532 | 19 | 9 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ARSENIC TRIOXIDE, CINTREDEKIN BESUDOTOX, IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090, AUROTHIOGLUCOSE, MOTEXAFIN GADOLINIUM |
| CMF-23077 | PDHA2 | down-regulates | RFX5 | activates | R-2068 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23537 | CKMT1A | down-regulates | RFX5 | activates | R-2068 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26488 | EGFR | up-regulates | RFX2 | activates | R-2298 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26994 | HMCN1 | down-regulates | RFX5 | activates | R-2068 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |