Program Pr-68

Genes (16)

SEPHS1, CUEDC2, FCHSD2, CCDC28B, ATPAF2, CTBP2, PUF60, PCGF2, ASCC1, GABARAP, TRIM8, RPRM, TXN2, FAM89B, FOXO4, ABHD6

Regulons (10)

R-94, R-148, R-428, R-607, R-824, R-913, R-2819, R-3353, R-3499, R-3601

Regulons in program Pr-68

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-94	-3.71052	8	4
R-148	-4.47419	9	6
R-428	-4.08993	12	2
R-607	-3.76322	12	8
R-824	-3.5586	10	5
R-913	-3.67208	14	7
R-2819	-3.31715	9	6
R-3353	-3.87379	10	13
R-3499	-2.99484	7	2
R-3601	-4.17237	5	11

Genes in program Pr-68

EnsEMBL Id	Entrez Id	Preferred
ENSG00000086475	22929	SEPHS1
ENSG00000107874	79004	CUEDC2
ENSG00000137478	9873	FCHSD2
ENSG00000160050	79140	CCDC28B
ENSG00000171953	91647	ATPAF2
ENSG00000175029	1488	CTBP2
ENSG00000274081	22827	PUF60
ENSG00000278644	7703	PCGF2
ENSG00000138303	51008	ASCC1
ENSG00000170296	11337	GABARAP
ENSG00000171206	81603	TRIM8
ENSG00000177519	56475	RPRM
ENSG00000100348	25828	TXN2
ENSG00000176973	23625	FAM89B
ENSG00000184481	4303	FOXO4
ENSG00000163686	57406	ABHD6

Causal Mechanistic Flows with Program Pr-68

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00255	SPTA1	down-regulates	HSF1	activates	R-94	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-00295	SPTA1	up-regulates	LTF	represses	R-3601	2	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-00743	DNAH5	down-regulates	MAZ	activates	R-607	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-00751	DNAH5	up-regulates	LTF	represses	R-3601	2	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01663	MMRN1	down-regulates	MAZ	activates	R-607	25	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-02455	DNAH9	down-regulates	ELF5	represses	R-3353	16	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-02966	ASZ1	down-regulates	ELF5	represses	R-3353	16	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04230	RBPJL	down-regulates	MAZ	activates	R-607	25	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04445	ADAM6	up-regulates	MSX1	activates	R-2819	12	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05466	KIAA1549	up-regulates	MSX1	activates	R-2819	12	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06170	MDGA2	down-regulates	MAZ	activates	R-607	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06751	ATRX	down-regulates	ELF5	represses	R-3353	16	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07064	ATRX	down-regulates	LTF	represses	R-3601	2	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07165	ATRX	up-regulates	ZNF281	activates	R-913	24	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10372	FGG	up-regulates	MSX1	activates	R-2819	12	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10591	ITIH5L	down-regulates	ELF5	represses	R-3353	16	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11302	RPTN	down-regulates	ELF5	represses	R-3353	16	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-12641	NUP205	down-regulates	MAZ	activates	R-607	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-12651	REN	down-regulates	LTF	represses	R-3601	2	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-13393	FMN1	down-regulates	ELF5	represses	R-3353	16	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14541	GABRA4	down-regulates	ELF5	represses	R-3353	16	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14639	C1orf177	up-regulates	LTF	represses	R-3601	2	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14691	PTPN11	down-regulates	HSF1	activates	R-94	4	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17075	MAGEA6	down-regulates	ZNF281	activates	R-913	24	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18425	FILIP1	down-regulates	MSX1	activates	R-2819	12	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18763	LY75	down-regulates	MSX1	activates	R-2819	12	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18765	LY75	down-regulates	ZNF281	activates	R-913	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19331	NF1	down-regulates	MAZ	activates	R-607	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19812	OR6C75	down-regulates	ELF5	represses	R-3353	16	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19827	OR6C75	up-regulates	MSX1	activates	R-2819	12	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20232	GPR15	up-regulates	LTF	represses	R-3601	2	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20336	FTMT	down-regulates	ELF5	represses	R-3353	16	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20344	FTMT	up-regulates	MAZ	activates	R-607	25	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20607	ADCY1	up-regulates	LTF	represses	R-3601	2	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22369	IDH1	down-regulates	ELF5	represses	R-3353	16	10	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22824	IDH1	down-regulates	LTF	represses	R-3601	2	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22976	IDH1	up-regulates	ZNF281	activates	R-913	24	15	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23492	CUBN	down-regulates	ELF5	represses	R-3353	16	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23579	TP53	up-regulates	HSF1	activates	R-94	4	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23982	TP53	down-regulates	LTF	represses	R-3601	2	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24106	TP53	up-regulates	ZNF281	activates	R-913	24	11	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26371	ZFHX4	down-regulates	ZNF281	activates	R-913	24	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26453	EGFR	down-regulates	HSF1	activates	R-94	4	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26464	EGFR	up-regulates	ELF5	represses	R-3353	16	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26497	EGFR	up-regulates	LTF	represses	R-3601	2	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26519	EGFR	down-regulates	ZNF281	activates	R-913	24	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27214	HTR3A	down-regulates	MAZ	activates	R-607	25	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-28906	NR1H4	up-regulates	LTF	represses	R-3601	2	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-30248	ACSM2B	down-regulates	ELF5	represses	R-3353	16	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)

Program

Pr-68

Program Pr-68

Genes (16)

Regulons (10)

Regulons in program Pr-68

Genes in program Pr-68

Causal Mechanistic Flows with Program Pr-68

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)