Program – gbmMINER Portal

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Program – gbmMINER Portal

Program

Program Pr-52

Genes (27)

RANBP9, TMEM131, PNPLA3, EEA1, CDK6, ITGB8, EYA4, VAPB, RNF6, ADAMTS3, TRAF6, FOXJ3, RNF24, CCNT1, RORA, FAM63B, GMPR2, LEPROTL1, SOCS2, TNFAIP6, ZNF557, PLAC8, NRBF2, RPL36AL, MGAT2, 2-Sep, RNF139

Regulons (15)

R-221, R-264, R-772, R-954, R-1110, R-1472, R-1565, R-1879, R-2004, R-2149, R-2386, R-2820, R-3283, R-3594, R-3764

Regulons in program Pr-52

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-221	1.41464	12	5
R-264	1.04522	11	5
R-772	1.61525	11	4
R-954	1.06753	11	4
R-1110	1.22725	11	5
R-1472	1.61241	7	5
R-1565	0.855276	24	10
R-1879	0.983498	8	1
R-2004	1.8247	9	19
R-2149	1.56321	8	3
R-2386	2.09401	8	15
R-2820	2.01802	9	4
R-3283	1.33894	5	13
R-3594	1.23484	7	3
R-3764	1.29858	6	18

Genes in program Pr-52

EnsEMBL Id	Entrez Id	Preferred
ENSG00000010017	10048	RANBP9
ENSG00000075568	23505	TMEM131
ENSG00000100344	80339	PNPLA3
ENSG00000102189	8411	EEA1
ENSG00000105810	1021	CDK6
ENSG00000105855	3696	ITGB8
ENSG00000112319	2070	EYA4
ENSG00000124164	9217	VAPB
ENSG00000127870	6049	RNF6
ENSG00000156140	9508	ADAMTS3
ENSG00000175104	7189	TRAF6
ENSG00000198815	22887	FOXJ3
ENSG00000101236	11237	RNF24
ENSG00000129315	904	CCNT1
ENSG00000069667	6095	RORA
ENSG00000128923	54629	FAM63B
ENSG00000100938	51292	GMPR2
ENSG00000104660	23484	LEPROTL1
ENSG00000120833	8835	SOCS2
ENSG00000123610	7130	TNFAIP6
ENSG00000130544	79230	ZNF557
ENSG00000145287	51316	PLAC8
ENSG00000148572	29982	NRBF2
ENSG00000165502	6166	RPL36AL
ENSG00000168282	4247	MGAT2
ENSG00000168385	4735	2-Sep
ENSG00000170881	11236	RNF139

Causal Mechanistic Flows with Program Pr-52

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-08200	TPO	up-regulates	MSX1	activates	R-2820	12	3	Drugs (13) Regulator Drugs (0) Regulon Drugs (13) TRILACICLIB, RIBOCICLIB, PALBOCICLIB, ABEMACICLIB, PHA-793887, AZD-5438, RIBOCICLIB SUCCINATE, TRILACICLIB DIHYDROCHLORIDE, UCN-01, ALVOCIDIB, RONICICLIB, AT-7519, ABITUZUMAB
CMF-13625	FMN1	up-regulates	MSX1	activates	R-2820	12	4	Drugs (13) Regulator Drugs (0) Regulon Drugs (13) TRILACICLIB, RIBOCICLIB, PALBOCICLIB, ABEMACICLIB, PHA-793887, AZD-5438, RIBOCICLIB SUCCINATE, TRILACICLIB DIHYDROCHLORIDE, UCN-01, ALVOCIDIB, RONICICLIB, AT-7519, ABITUZUMAB
CMF-18356	SHB	up-regulates	MSX1	activates	R-2820	12	1	Drugs (13) Regulator Drugs (0) Regulon Drugs (13) TRILACICLIB, RIBOCICLIB, PALBOCICLIB, ABEMACICLIB, PHA-793887, AZD-5438, RIBOCICLIB SUCCINATE, TRILACICLIB DIHYDROCHLORIDE, UCN-01, ALVOCIDIB, RONICICLIB, AT-7519, ABITUZUMAB
CMF-31270	SHP2_SIGNALING	up-regulates	MSX1	activates	R-2820	12	2	Drugs (13) Regulator Drugs (0) Regulon Drugs (13) TRILACICLIB, RIBOCICLIB, PALBOCICLIB, ABEMACICLIB, PHA-793887, AZD-5438, RIBOCICLIB SUCCINATE, TRILACICLIB DIHYDROCHLORIDE, UCN-01, ALVOCIDIB, RONICICLIB, AT-7519, ABITUZUMAB

CMFlow summary not available

Enrichment summary not available