Program Pr-32

Genes (18)

VIM, NAGLU, THBS4, KLF9, ITPR2, EMP3, DIRAS3, SCG2, MXRA7, C21orf62, GADD45B, SREBF1, FNDC4, KCNJ8, CDKN1A, RHOB, KCNE4, HTRA1

Regulons (9)

R-589, R-710, R-1231, R-1275, R-1534, R-2975, R-3111, R-3430, R-3652

Regulons in program Pr-32

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-589	4.25758	10	14
R-710	3.92004	10	7
R-1231	3.81209	9	15
R-1275	3.07161	7	28
R-1534	3.03255	6	20
R-2975	3.65346	5	51
R-3111	3.97187	9	7
R-3430	3.27395	6	4
R-3652	3.63976	5	58

Genes in program Pr-32

EnsEMBL Id	Entrez Id	Preferred
ENSG00000026025	7431	VIM
ENSG00000108784	4669	NAGLU
ENSG00000113296	7060	THBS4
ENSG00000119138	687	KLF9
ENSG00000123104	3709	ITPR2
ENSG00000142227	2014	EMP3
ENSG00000162595	9077	DIRAS3
ENSG00000171951	7857	SCG2
ENSG00000182534	439921	MXRA7
ENSG00000262938	56245	C21orf62
ENSG00000099860	4616	GADD45B
ENSG00000072310	6720	SREBF1
ENSG00000115226	64838	FNDC4
ENSG00000121361	3764	KCNJ8
ENSG00000124762	1026	CDKN1A
ENSG00000143878	388	RHOB
ENSG00000152049	23704	KCNE4
ENSG00000166033	5654	HTRA1

Causal Mechanistic Flows with Program Pr-32

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-04492	MYH8	down-regulates	FOXO4	represses	R-3111	17	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07186	ATRX	up-regulates	FOXO4	represses	R-3111	17	12	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07968	OR5D13	up-regulates	FOXO1	activates	R-710	21	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-08840	FBLN2	up-regulates	SP3	activates	R-3430	12	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11004	BMP5	up-regulates	SP3	activates	R-3430	12	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11452	CYP4F22	down-regulates	FOXO4	represses	R-3111	17	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14476	PRKCD	down-regulates	FOXO1	activates	R-710	21	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14937	SDHAP3	up-regulates	SP3	activates	R-3430	12	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15754	FN1	down-regulates	FOXO4	represses	R-3111	17	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20746	ALPK1	down-regulates	FOXO4	represses	R-3111	17	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23007	IDH1	up-regulates	FOXO4	represses	R-3111	17	14	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24122	TP53	up-regulates	FOXO4	represses	R-3111	17	9	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24297	SMCHD1	up-regulates	FOXO1	activates	R-710	21	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24458	SEMA3C	down-regulates	FOXO1	activates	R-710	21	10	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27014	DNAH5	up-regulates	FOXO1	activates	R-710	21	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-29770	SLC5A7	up-regulates	FOXO1	activates	R-710	21	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-29979	GNAT3	up-regulates	FOXO1	activates	R-710	21	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-29984	GNAT3	up-regulates	SP3	activates	R-3430	12	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)

Program

Pr-32

Program Pr-32

Genes (18)

Regulons (9)

Regulons in program Pr-32

Genes in program Pr-32

Causal Mechanistic Flows with Program Pr-32

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