Program Pr-24

Genes (11)

IL6ST, UGCG, ARID5B, DLC1, KBTBD2, UBE2H, ARL4A, APP, DPY19L1, CHL1, B4GALT5

Regulons (12)

R-170, R-1555, R-1880, R-1961, R-2185, R-2387, R-2735, R-2823, R-3068, R-3176, R-3394, R-3768

Regulons in program Pr-24

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-170	1.75406	6	6
R-1555	1.67284	5	7
R-1880	1.9588	8	6
R-1961	1.77744	5	3
R-2185	2.78405	7	13
R-2387	1.94835	7	23
R-2735	0.460215	5	10
R-2823	1.79523	8	7
R-3068	1.49978	6	16
R-3176	3.14607	5	24
R-3394	1.67719	7	27
R-3768	1.34568	7	19

Genes in program Pr-24

EnsEMBL Id	Entrez Id	Preferred
ENSG00000134352	3572	IL6ST
ENSG00000148154	7357	UGCG
ENSG00000150347	84159	ARID5B
ENSG00000164741	10395	DLC1
ENSG00000170852	25948	KBTBD2
ENSG00000186591	7328	UBE2H
ENSG00000122644	10124	ARL4A
ENSG00000142192	351	APP
ENSG00000173852	23333	DPY19L1
ENSG00000134121	10752	CHL1
ENSG00000158470	9334	B4GALT5

Causal Mechanistic Flows with Program Pr-24

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00031	LRP2	up-regulates	ZBTB16	activates	R-2185	16	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-01882	CYP4F8	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-02791	DHX30	down-regulates	SIX6	represses	R-3176	4	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-02879	SRRM2	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-04390	ATP8B3	up-regulates	ZBTB16	activates	R-2185	16	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-07411	THOC2	down-regulates	SIX6	represses	R-3176	4	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-07951	F5	up-regulates	ZBTB16	activates	R-2185	16	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-07956	F5	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-07989	OR5D13	down-regulates	SIX6	represses	R-3176	4	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-11158	ODF4	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-11412	CYP4F22	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-11756	RAD51AP2	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-15394	DSE	down-regulates	SIX6	represses	R-3176	4	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-15541	TAS2R41	down-regulates	SIX6	represses	R-3176	4	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-16418	SUSD5	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-16983	CHRM2	up-regulates	ZBTB16	activates	R-2185	16	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-18294	MEGF8	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-18729	ARHGAP21	up-regulates	ZBTB16	activates	R-2185	16	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-19070	COL4A4	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-19327	NF1	down-regulates	SIX6	represses	R-3176	4	4	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-20129	TDRD9	down-regulates	SIX6	represses	R-3176	4	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-20709	ALPK1	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-21346	GRIK3	down-regulates	SIX6	represses	R-3176	4	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-21899	PRAME	down-regulates	SIX6	represses	R-3176	4	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-22073	SSTR4	down-regulates	SIX6	represses	R-3176	4	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-23210	RNF17	down-regulates	SIX6	represses	R-3176	4	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-23538	CKMT1A	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-24281	SMCHD1	up-regulates	ZBTB16	activates	R-2185	16	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-24437	SEMA3C	down-regulates	ZBTB16	activates	R-2185	16	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-24830	SULT1B1	up-regulates	ZBTB16	activates	R-2185	16	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-25844	KDM2B	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-25927	PRKG2	up-regulates	ZBTB16	activates	R-2185	16	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-26995	HMCN1	down-regulates	SIX6	represses	R-3176	4	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-27011	DNAH5	up-regulates	ZBTB16	activates	R-2185	16	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-27072	NBAS	up-regulates	ZBTB16	activates	R-2185	16	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-28699	TRPS1	up-regulates	ZBTB16	activates	R-2185	16	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-29756	SLC5A7	up-regulates	ZBTB16	activates	R-2185	16	4	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT

Program

Pr-24

Program Pr-24

Genes (11)

Regulons (12)

Regulons in program Pr-24

Genes in program Pr-24

Causal Mechanistic Flows with Program Pr-24

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