Program – gbmMINER Portal

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Program – gbmMINER Portal

Program

Program Pr-19

Genes (34)

DCN, IFNGR1, SEL1L, SNAP23, TFEC, LRMP, PRKAA1, GIMAP6, FAM105A, SMPDL3A, KCTD12, MGAT4A, FKBP1A, CREM, FCGRT, KCNJ5, SNX6, GMFG, TM6SF1, ITGAX, PLA2G7, CD69, HHEX, ARHGAP25, IRF8, CLEC4A, CETP, MAP3K8, FRMD4B, PLAGL1, TBC1D4, CTSK, RASGRP3, GAS6

Regulons (14)

R-164, R-316, R-653, R-1269, R-1594, R-1755, R-1787, R-2786, R-2796, R-2810, R-2986, R-3058, R-3560, R-3605

Regulons in program Pr-19

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-164	1.33521	11	7
R-316	1.23686	19	16
R-653	1.09694	20	18
R-1269	1.43191	6	5
R-1594	1.18615	24	9
R-1755	2.14798	6	3
R-1787	1.16903	23	13
R-2786	1.24256	9	8
R-2796	1.44211	8	3
R-2810	1.16981	11	5
R-2986	1.63419	6	12
R-3058	1.62028	8	4
R-3560	0.969762	5	9
R-3605	1.51999	6	14

Genes in program Pr-19

EnsEMBL Id	Entrez Id	Preferred
ENSG00000011465	1634	DCN
ENSG00000027697	3459	IFNGR1
ENSG00000071537	6400	SEL1L
ENSG00000092531	8773	SNAP23
ENSG00000105967	22797	TFEC
ENSG00000118308	4033	LRMP
ENSG00000132356	5562	PRKAA1
ENSG00000133561	474344	GIMAP6
ENSG00000145569	54491	FAM105A
ENSG00000172594	10924	SMPDL3A
ENSG00000178695	115207	KCTD12
ENSG00000071073	11320	MGAT4A
ENSG00000088832	2280	FKBP1A
ENSG00000095794	1390	CREM
ENSG00000104870	2217	FCGRT
ENSG00000120457	3762	KCNJ5
ENSG00000129515	58533	SNX6
ENSG00000130755	9535	GMFG
ENSG00000136404	53346	TM6SF1
ENSG00000140678	3687	ITGAX
ENSG00000146070	7941	PLA2G7
ENSG00000110848	969	CD69
ENSG00000152804	3087	HHEX
ENSG00000163219	9938	ARHGAP25
ENSG00000140968	3394	IRF8
ENSG00000111729	50856	CLEC4A
ENSG00000087237	1071	CETP
ENSG00000107968	1326	MAP3K8
ENSG00000114541	23150	FRMD4B
ENSG00000118495	5325	PLAGL1
ENSG00000136111	9882	TBC1D4
ENSG00000143387	1513	CTSK
ENSG00000152689	25780	RASGRP3
ENSG00000183087	2621	GAS6

Causal Mechanistic Flows with Program Pr-19

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-03901	DSP	down-regulates	BARX2	represses	R-1755	7	3	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) BATOCLIMAB, NIPOCALIMAB, EFGARTIGIMOD ALFA, ROZANOLIXIZUMAB, VERNAKALANT, VERNAKALANT HYDROCHLORIDE
CMF-12701	ABCA10	down-regulates	BARX2	represses	R-1755	7	1	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) BATOCLIMAB, NIPOCALIMAB, EFGARTIGIMOD ALFA, ROZANOLIXIZUMAB, VERNAKALANT, VERNAKALANT HYDROCHLORIDE
CMF-15422	DSE	down-regulates	BARX2	represses	R-1755	7	3	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) BATOCLIMAB, NIPOCALIMAB, EFGARTIGIMOD ALFA, ROZANOLIXIZUMAB, VERNAKALANT, VERNAKALANT HYDROCHLORIDE

CMFlow summary not available

Enrichment summary not available