Program Pr-168

Genes (8)

CUL1, SMS, GARS, CDR2, HS3ST3A1, ARPC1A, HMGA2, KIRREL

Regulons (5)

R-347, R-2016, R-2406, R-2903, R-3475

Regulons in program Pr-168

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-347	2.69499	6	12
R-2016	2.19753	5	12
R-2406	2.7097	5	6
R-2903	2.64187	8	3
R-3475	2.51555	7	8

Genes in program Pr-168

EnsEMBL Id	Entrez Id	Preferred
ENSG00000055130	8454	CUL1
ENSG00000102172	6611	SMS
ENSG00000106105	2617	GARS
ENSG00000140743	1039	CDR2
ENSG00000153976	9955	HS3ST3A1
ENSG00000241685	10552	ARPC1A
ENSG00000149948	8091	HMGA2
ENSG00000183853	55243	KIRREL

Causal Mechanistic Flows with Program Pr-168

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-02526	MMP3	up-regulates	TBP	activates	R-3475	18	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-02558	HECW1	up-regulates	TBP	activates	R-3475	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05872	ZNF813	up-regulates	TBP	activates	R-3475	18	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07417	THOC2	down-regulates	LHX3	represses	R-2016	24	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-08436	COL17A1	down-regulates	LHX3	represses	R-2016	24	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11345	KCNT1	down-regulates	LHX3	represses	R-2016	24	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-13802	ADAMTS8	up-regulates	LHX3	represses	R-2016	24	9	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14548	GABRA4	up-regulates	TBP	activates	R-3475	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15187	ERCC6	down-regulates	TBP	activates	R-3475	18	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-16598	KRTAP5-4	up-regulates	TBP	activates	R-3475	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19931	ACTL9	down-regulates	LHX3	represses	R-2016	24	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20749	DSG4	down-regulates	LHX3	represses	R-2016	24	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20755	TLR7	up-regulates	TBP	activates	R-3475	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22576	IDH1	up-regulates	LHX3	represses	R-2016	24	21	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-25142	FLT3	down-regulates	LHX3	represses	R-2016	24	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26587	NAALADL1	down-regulates	LHX3	represses	R-2016	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27091	NBAS	up-regulates	TBP	activates	R-3475	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-28716	TSHZ2	down-regulates	LHX3	represses	R-2016	24	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-29496	SEMA3E	down-regulates	LHX3	represses	R-2016	24	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-30020	MORC1	down-regulates	LHX3	represses	R-2016	24	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-34208	MMP3	down-regulates	hsa-mir-490	represses	R-3475	35	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-34420	PTPRM	down-regulates	hsa-mir-338	represses	R-3475	79	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-34651	MYH8	down-regulates	hsa-mir-129	represses	R-3475	155	50	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-34660	MYH8	down-regulates	hsa-mir-129	represses	R-2016	155	50	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-34697	LAMC3	down-regulates	hsa-mir-150	represses	R-2016	1	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-34833	ITPR3	down-regulates	hsa-mir-488	represses	R-2016	19	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-34849	ITPR3	down-regulates	hsa-mir-338	represses	R-2016	79	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-35943	THOC2	down-regulates	hsa-mir-338	represses	R-2016	79	26	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-36224	ABCC4	down-regulates	hsa-mir-490	represses	R-3475	35	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-36373	DIAPH2	up-regulates	hsa-mir-488	represses	R-2016	19	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-37024	ATF7IP2	down-regulates	hsa-mir-129	represses	R-3475	155	20	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-37149	KCNT1	down-regulates	hsa-mir-150	represses	R-2016	1	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-37248	RAD51AP2	down-regulates	hsa-mir-490	represses	R-3475	35	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-37261	RAD51AP2	down-regulates	hsa-mir-129	represses	R-3475	155	17	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-37593	CLYBL	down-regulates	hsa-mir-491	represses	R-3475	15	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-37988	SDHAP3	down-regulates	hsa-mir-488	represses	R-2016	19	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-38051	KCNQ5	down-regulates	hsa-mir-129	represses	R-3475	155	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-38303	LARP1	up-regulates	hsa-mir-150	represses	R-2016	1	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-38534	SEZ6L2	up-regulates	hsa-mir-150	represses	R-2016	1	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-38535	KRTAP5-4	down-regulates	hsa-mir-490	represses	R-3475	35	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-38536	KRTAP5-4	down-regulates	hsa-mir-491	represses	R-3475	15	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-38721	TIE1	down-regulates	hsa-mir-129	represses	R-2016	155	58	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-39534	NF1	down-regulates	hsa-mir-488	represses	R-2016	19	12	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-39540	NF1	down-regulates	hsa-mir-150	represses	R-2016	1	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-39880	ACTL9	down-regulates	hsa-mir-488	represses	R-2016	19	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-39881	ACTL9	down-regulates	hsa-mir-150	represses	R-2016	1	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-40650	IDH1	up-regulates	hsa-mir-488	represses	R-2016	19	14	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-41931	FLT3	down-regulates	hsa-mir-488	represses	R-2016	19	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-41933	FLT3	down-regulates	hsa-mir-490	represses	R-3475	35	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-41997	FBN3	down-regulates	hsa-mir-490	represses	R-3475	35	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-42197	NAALADL1	down-regulates	hsa-mir-338	represses	R-2016	79	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-42248	VAV1	down-regulates	hsa-mir-491	represses	R-3475	15	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-42707	TSHZ2	down-regulates	hsa-mir-150	represses	R-2016	1	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-42708	TSHZ2	down-regulates	hsa-mir-490	represses	R-3475	35	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-42950	SEMA3E	down-regulates	hsa-mir-129	represses	R-2016	155	54	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-43241	RNF130	up-regulates	hsa-mir-338	represses	R-2016	79	29	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)

Program

Pr-168

Program Pr-168

Genes (8)

Regulons (5)

Regulons in program Pr-168

Genes in program Pr-168

Causal Mechanistic Flows with Program Pr-168

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