Program

Program Pr-155

Genes (50)

MAP2K3, CUL7, PVR, SLC12A4, SDC4, TRIP10, LDLR, TRPM4, LAMA5, DUSP5, FURIN, EPHA2, OSBPL10, RRP1, LMNA, NPAS2, DHCR7, RCE1, PHLDA3, FOSL1, CD151, EPHB4, SIPA1L1, CRIM1, SBNO2, ACTN4, PNKP, PRKACA, RRBP1, PML, ERBB2, NAB2, SSH3, BCAM, PARVB, TEAD3, HOMER2, SH2D4A, ARSJ, EHD2, XYLT2, MAP2K7, TOM1, KLHDC4, EPS8L1, LRPAP1, MFSD7, TRABD, PNPLA2, ALG12

Regulons (17)

R-211, R-373, R-793, R-966, R-996, R-1484, R-1773, R-2346, R-2350, R-2472, R-2475, R-2496, R-2508, R-2526, R-2530, R-2534, R-2538

Regulons in program Pr-155

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-211	2.63638	26	20
R-373	2.71651	32	12
R-793	2.20911	17	2
R-966	1.70606	8	3
R-996	3.12944	20	14
R-1484	2.96899	21	17
R-1773	2.50595	17	9
R-2346	2.773	29	14
R-2350	0.863643	10	11
R-2472	2.58004	17	6
R-2475	2.42255	19	10
R-2496	1.74707	12	15
R-2508	2.55492	16	7
R-2526	2.29712	7	7
R-2530	1.85706	8	6
R-2534	1.55974	9	15
R-2538	2.39491	17	9

Genes in program Pr-155

EnsEMBL Id	Entrez Id	Preferred
ENSG00000034152	5606	MAP2K3
ENSG00000044090	9820	CUL7
ENSG00000073008	5817	PVR
ENSG00000124067	6560	SLC12A4
ENSG00000124145	6385	SDC4
ENSG00000125733	9322	TRIP10
ENSG00000130164	3949	LDLR
ENSG00000130529	54795	TRPM4
ENSG00000130702	3911	LAMA5
ENSG00000138166	1847	DUSP5
ENSG00000140564	5045	FURIN
ENSG00000142627	1969	EPHA2
ENSG00000144645	114884	OSBPL10
ENSG00000160214	8568	RRP1
ENSG00000160789	4000	LMNA
ENSG00000170485	4862	NPAS2
ENSG00000172893	1717	DHCR7
ENSG00000173653	9986	RCE1
ENSG00000174307	23612	PHLDA3
ENSG00000175592	8061	FOSL1
ENSG00000177697	977	CD151
ENSG00000196411	2050	EPHB4
ENSG00000197555	26037	SIPA1L1
ENSG00000277354	51232	CRIM1
ENSG00000278788	22904	SBNO2
ENSG00000282844	81	ACTN4
ENSG00000039650	11284	PNKP
ENSG00000072062	5566	PRKACA
ENSG00000125844	6238	RRBP1
ENSG00000140464	5371	PML
ENSG00000141736	2064	ERBB2
ENSG00000166886	4665	NAB2
ENSG00000172830	54961	SSH3
ENSG00000187244	4059	BCAM
ENSG00000188677	29780	PARVB
ENSG00000007866	7005	TEAD3
ENSG00000103942	9455	HOMER2
ENSG00000104611	63898	SH2D4A
ENSG00000180801	79642	ARSJ
ENSG00000024422	30846	EHD2
ENSG00000015532	64132	XYLT2
ENSG00000076984	5609	MAP2K7
ENSG00000100284	10043	TOM1
ENSG00000104731	54758	KLHDC4
ENSG00000131037	54869	EPS8L1
ENSG00000163956	4043	LRPAP1
ENSG00000169026	84179	MFSD7
ENSG00000170638	80305	TRABD
ENSG00000177666	57104	PNPLA2
ENSG00000182858	79087	ALG12

Causal Mechanistic Flows with Program Pr-155

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00332	COL6A3	up-regulates	JUN	activates	R-211	25	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-00364	COL6A3	up-regulates	PLAG1	activates	R-2508	5	4	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-00579	HMCN1	up-regulates	EGR1	activates	R-996	20	10	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-00609	HMCN1	up-regulates	JUN	activates	R-211	25	14	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-00614	HMCN1	down-regulates	SP4	represses	R-2346	8	4	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-00721	HMCN1	up-regulates	SMAD1	activates	R-1484	21	7	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-01103	ZNF292	down-regulates	SPI1	activates	R-373	25	12	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-01154	ZNF292	down-regulates	PLAG1	activates	R-2508	5	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-01472	MTOR	down-regulates	SP4	represses	R-2346	8	1	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-01804	TMPRSS15	up-regulates	EGR1	activates	R-996	20	5	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-02010	TCHH	down-regulates	PITX1	activates	R-2472	3	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) DASATINIB, VANDETANIB, REGORAFENIB
CMF-02249	GPR65	up-regulates	SMAD3	activates	R-2538	15	2	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-02714	ABCA5	up-regulates	SMAD3	activates	R-2538	15	2	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-02731	ABCA5	up-regulates	SMAD1	activates	R-1484	21	1	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-03440	ZNF28	down-regulates	JUN	activates	R-211	25	3	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-04139	KIAA2026	up-regulates	SP4	represses	R-2346	8	1	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-04915	ABCC5	down-regulates	IRF7	activates	R-2475	21	9	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB
CMF-05755	ADAMTS19	down-regulates	TP53	activates	R-1773	13	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-06173	MDGA2	down-regulates	SP4	represses	R-2346	8	1	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-06795	ATRX	down-regulates	IRF7	activates	R-2475	21	19	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB
CMF-06841	ATRX	down-regulates	EGR1	activates	R-996	20	12	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-07526	ANO7	down-regulates	TP53	activates	R-1773	13	5	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-08460	MSL3	down-regulates	PITX1	activates	R-2472	3	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) DASATINIB, VANDETANIB, REGORAFENIB
CMF-08478	MSL3	down-regulates	JUN	activates	R-211	25	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-08594	FOXR2	down-regulates	EGR1	activates	R-996	20	5	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-09027	NALCN	down-regulates	JUN	activates	R-211	25	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-09068	FLT1	down-regulates	SPI1	activates	R-373	25	2	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-09070	FLT1	down-regulates	IRF7	activates	R-2475	21	3	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB
CMF-09350	SPTA1	down-regulates	SMAD1	activates	R-1484	21	2	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-09426	ZIC4	up-regulates	JUN	activates	R-211	25	2	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-09456	ZIC4	up-regulates	SMAD1	activates	R-1484	21	2	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-09476	DOCK11	up-regulates	TP53	activates	R-1773	13	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-10055	ATP8A2	up-regulates	SP4	represses	R-2346	8	2	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-10100	TACR3	down-regulates	SPI1	activates	R-373	25	3	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-10116	PCDHGA8	down-regulates	IRF7	activates	R-2475	21	2	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB
CMF-10516	LRBA	up-regulates	EGR1	activates	R-996	20	7	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-10568	LRBA	up-regulates	SMAD1	activates	R-1484	21	5	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-11395	CYP4F22	up-regulates	TP53	activates	R-1773	13	4	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-11841	SKIV2L	down-regulates	SP4	represses	R-2346	8	1	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-12262	GPR98	down-regulates	SPI1	activates	R-373	25	13	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-12306	GPR98	down-regulates	ZFX	activates	R-793	23	8	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB, GSK-690693
CMF-12376	GPR98	down-regulates	PLAG1	activates	R-2508	5	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-12934	HTR3E	down-regulates	JUN	activates	R-211	25	10	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-13068	OTC	up-regulates	SPI1	activates	R-373	25	3	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-13644	FMN1	up-regulates	SMAD1	activates	R-1484	21	11	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-13781	ADAMTS8	down-regulates	SPI1	activates	R-373	25	12	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-13786	ADAMTS8	down-regulates	EGR1	activates	R-996	20	3	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-13794	ADAMTS8	down-regulates	JUN	activates	R-211	25	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-14133	CD1D	up-regulates	SPI1	activates	R-373	25	5	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-14388	SLC4A1	down-regulates	SP4	represses	R-2346	8	1	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-14485	PRKCD	down-regulates	EGR1	activates	R-996	20	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-15274	HCN1	up-regulates	EGR1	activates	R-996	20	11	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-15281	HCN1	down-regulates	SP4	represses	R-2346	8	2	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-15653	DCHS2	up-regulates	JUN	activates	R-211	25	9	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-15701	DCHS2	up-regulates	SMAD1	activates	R-1484	21	4	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-15790	GRM3	up-regulates	IRF7	activates	R-2475	21	7	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB
CMF-15795	GRM3	up-regulates	JUN	activates	R-211	25	1	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-15820	GRM3	up-regulates	SMAD1	activates	R-1484	21	1	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-16618	KRTAP5-4	up-regulates	SMAD1	activates	R-1484	21	2	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-16997	FLNA	down-regulates	SPI1	activates	R-373	25	2	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-17085	A2BP1	down-regulates	IRF7	activates	R-2475	21	2	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB
CMF-17593	ODZ1	down-regulates	TP53	activates	R-1773	13	5	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-17619	ODZ1	down-regulates	SMAD3	activates	R-2538	15	3	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-17686	MRPL32	down-regulates	PLAG1	activates	R-2508	5	1	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-18516	LAMA1	up-regulates	SMAD1	activates	R-1484	21	6	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-18702	MPP7	down-regulates	IRF7	activates	R-2475	21	6	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB
CMF-18722	MPP7	down-regulates	SMAD1	activates	R-1484	21	5	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-19310	NF1	up-regulates	EGR1	activates	R-996	20	10	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-19362	NF1	up-regulates	JUN	activates	R-211	25	16	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-19365	NF1	down-regulates	SP4	represses	R-2346	8	3	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-19428	NF1	up-regulates	SMAD3	activates	R-2538	15	7	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-19597	NF1	up-regulates	PLAG1	activates	R-2508	5	4	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-19615	USP6	down-regulates	PITX1	activates	R-2472	3	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) DASATINIB, VANDETANIB, REGORAFENIB
CMF-20271	ENAM	down-regulates	JUN	activates	R-211	25	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-20272	ENAM	up-regulates	SP4	represses	R-2346	8	1	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-21131	COL22A1	down-regulates	PITX1	activates	R-2472	3	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) DASATINIB, VANDETANIB, REGORAFENIB
CMF-21157	ADAM30	up-regulates	PITX1	activates	R-2472	3	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) DASATINIB, VANDETANIB, REGORAFENIB
CMF-21165	ADAM30	down-regulates	SP4	represses	R-2346	8	2	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-21262	EGR1	up-regulates	SMAD3	activates	R-2538	15	3	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-21430	GRIK3	up-regulates	SMAD1	activates	R-1484	21	4	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-22145	PDGFRA	down-regulates	SPI1	activates	R-373	25	9	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-22435	IDH1	down-regulates	IRF7	activates	R-2475	21	20	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB
CMF-22487	IDH1	down-regulates	EGR1	activates	R-996	20	13	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-23224	RNF17	up-regulates	JUN	activates	R-211	25	8	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-23322	PABPC3	down-regulates	JUN	activates	R-211	25	2	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-23347	CCDC132	up-regulates	SMAD1	activates	R-1484	21	4	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-23717	TP53	down-regulates	SPI1	activates	R-373	25	15	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-23791	TP53	up-regulates	SP4	represses	R-2346	8	5	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-24082	TP53	down-regulates	SMAD1	activates	R-1484	21	12	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-24507	SEMA3C	down-regulates	SMAD3	activates	R-2538	15	6	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-24562	SEMA3C	down-regulates	SMAD1	activates	R-1484	21	6	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-24781	HIST1H2BE	up-regulates	PITX1	activates	R-2472	3	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) DASATINIB, VANDETANIB, REGORAFENIB
CMF-25220	CPNE7	up-regulates	SMAD3	activates	R-2538	15	1	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-25444	PCDHGB3	up-regulates	SMAD3	activates	R-2538	15	4	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-26315	CHGB	up-regulates	EGR1	activates	R-996	20	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-26997	HMCN1	up-regulates	JUN	activates	R-211	25	2	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-27742	C21orf29	down-regulates	IRF7	activates	R-2475	21	1	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB
CMF-28077	CELSR3	down-regulates	JUN	activates	R-211	25	9	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-28455	MYO9B	down-regulates	PLAG1	activates	R-2508	5	4	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-28673	PCNX	down-regulates	SMAD1	activates	R-1484	21	3	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-28762	MLL4	down-regulates	EGR1	activates	R-996	20	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-28766	MLL4	down-regulates	JUN	activates	R-211	25	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-29069	DNAH3	up-regulates	SMAD3	activates	R-2538	15	1	Drugs (44) Regulator Drugs (0) Regulon Drugs (44) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-29138	FOLH1B	down-regulates	PLAG1	activates	R-2508	5	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-29194	AQP10	down-regulates	SPI1	activates	R-373	25	8	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-29208	AQP10	up-regulates	SP4	represses	R-2346	8	3	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-29259	NEU2	down-regulates	IRF7	activates	R-2475	21	2	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB
CMF-29494	SEMA3E	up-regulates	JUN	activates	R-211	25	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-29627	ESRRB	down-regulates	EGR1	activates	R-996	20	11	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OCRIPLASMIN, GSK-690693
CMF-29647	ESRRB	down-regulates	JUN	activates	R-211	25	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-29872	ABCC9	up-regulates	JUN	activates	R-211	25	8	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, REGORAFENIB
CMF-30060	FAM126B	down-regulates	SP4	represses	R-2346	8	2	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-30374	RNF130	down-regulates	SPI1	activates	R-373	25	5	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-30385	RNF130	down-regulates	SMAD1	activates	R-1484	21	3	Drugs (41) Regulator Drugs (0) Regulon Drugs (41) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, AFATINIB DIMALEATE, CP-724714, AFATINIB, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GANCOTAMAB
CMF-31513	EGF_RECEPTOR_SIGNALING_PATHWAY	up-regulates	TP53	activates	R-1773	13	6	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-32781	E_CADHERIN_SIGNALING_IN_KERATINOCYTES	up-regulates	TP53	activates	R-1773	13	7	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693
CMF-33303	ERBB1_DOWNSTREAM_SIGNALING	up-regulates	TP53	activates	R-1773	13	7	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) DASATINIB, VANDETANIB, REGORAFENIB, GSK-690693

Pr-155

Program Pr-155

Genes (50)

Regulons (17)

Regulons in program Pr-155

Genes in program Pr-155

Causal Mechanistic Flows with Program Pr-155

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