Pr-10
Genes (62)
TRAF1, CTF1, SQSTM1, BNC2, HHAT, DNAJC3, NRP2, PIM1, CYR61, ZDHHC7, PXN, AHNAK, COL6A1, LMNA, COL3A1, AHNAK2, ST3GAL1, VCL, NFKB1, FN1, FURIN, STAT6, EHBP1L1, TMEM109, TGOLN2, FBN1, FLII, MYO1C, MANBA, GIT2, PRRX1, PIK3CA, CHD1L, GALNT10, AKAP13, PLXNA1, EDEM1, TBC1D2B, FLNA, GCNT1, HEBP1, HGF, RAB36, ANXA13, PDLIM4, TRAM2, ELF4, ITGB5, DKK1, HLCS, GEM, TPP1, IRAK1, COL15A1, PANX1, PLOD2, KLHL21, IL2RB, APOL3, TLN1, TNIP1, TBC1D8Regulons (30)
R-111, R-200, R-231, R-365, R-467, R-1422, R-1423, R-1425, R-1530, R-1581, R-1617, R-1776, R-2107, R-2108, R-2122, R-2241, R-2269, R-2344, R-2512, R-2749, R-3097, R-3138, R-3271, R-3303, R-3366, R-3390, R-3567, R-3607, R-3668, R-3758Regulons in program Pr-10
| Regulon | Cox Hazard Ratio | # genes | # causal flows |
|---|---|---|---|
| R-111 | 3.6371 | 5 | 7 |
| R-200 | 1.36803 | 5 | 8 |
| R-231 | 2.97932 | 6 | 11 |
| R-365 | 2.07657 | 7 | 7 |
| R-467 | 2.6821 | 7 | 4 |
| R-1422 | 1.44877 | 5 | 10 |
| R-1423 | 0.381592 | 5 | 1 |
| R-1425 | 3.11692 | 5 | 7 |
| R-1530 | 2.34269 | 8 | 14 |
| R-1581 | 1.61694 | 7 | 6 |
| R-1617 | 4.18778 | 7 | 6 |
| R-1776 | 2.56959 | 10 | 10 |
| R-2107 | 2.55391 | 7 | 19 |
| R-2108 | 1.23359 | 6 | 33 |
| R-2122 | 2.75189 | 5 | 10 |
| R-2241 | 4.03819 | 8 | 4 |
| R-2269 | 1.77666 | 9 | 11 |
| R-2344 | 2.6917 | 5 | 8 |
| R-2512 | 2.86615 | 5 | 10 |
| R-2749 | 2.4861 | 8 | 12 |
| R-3097 | 1.77825 | 11 | 16 |
| R-3138 | 2.25443 | 9 | 13 |
| R-3271 | 1.58202 | 5 | 8 |
| R-3303 | 1.42168 | 5 | 5 |
| R-3366 | 2.35898 | 7 | 10 |
| R-3390 | 2.25675 | 5 | 4 |
| R-3567 | 1.49328 | 7 | 7 |
| R-3607 | 1.68992 | 6 | 6 |
| R-3668 | 2.57573 | 5 | 4 |
| R-3758 | 2.11975 | 10 | 5 |
Genes in program Pr-10
Causal Mechanistic Flows with Program Pr-10
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00327 | COL6A3 | up-regulates | TEAD3 | activates | R-2107 | 15 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-00330 | COL6A3 | up-regulates | JUN | activates | R-231 | 25 | 4 | Drugs (2) |
| CMF-00365 | COL6A3 | up-regulates | PLAG1 | activates | R-2512 | 5 | 4 | Drugs (2) |
| CMF-00602 | HMCN1 | up-regulates | JUN | activates | R-231 | 25 | 14 | Drugs (2) |
| CMF-00768 | TPTE2 | down-regulates | TEAD3 | activates | R-2107 | 15 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-01468 | MTOR | up-regulates | JUN | activates | R-231 | 25 | 7 | Drugs (2) |
| CMF-01627 | MCM6 | up-regulates | IKZF1 | activates | R-3138 | 16 | 6 | Drugs (5) |
| CMF-01636 | MCM6 | down-regulates | HOXD13 | represses | R-3758 | 1 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-01919 | PCDH9 | down-regulates | TEAD4 | activates | R-3366 | 6 | 4 | Drugs (5) |
| CMF-02047 | CNGA4 | up-regulates | TEAD4 | activates | R-3366 | 6 | 1 | Drugs (5) |
| CMF-02126 | ABCA4 | up-regulates | JUN | activates | R-231 | 25 | 3 | Drugs (2) |
| CMF-02383 | LRP2 | up-regulates | STAT3 | activates | R-1530 | 25 | 7 | Drugs (5) |
| CMF-02416 | LRP2 | up-regulates | KLF4 | activates | R-2122 | 10 | 2 | Drugs (2) |
| CMF-02796 | DHX30 | up-regulates | IKZF1 | activates | R-3138 | 16 | 4 | Drugs (5) |
| CMF-03027 | OR5D14 | up-regulates | STAT3 | activates | R-1530 | 25 | 4 | Drugs (5) |
| CMF-03270 | HRNR | down-regulates | NFAT5 | activates | R-3668 | 4 | 1 | Drugs (5) |
| CMF-03393 | CCDC60 | down-regulates | TP53 | activates | R-1776 | 13 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-04012 | DSP | up-regulates | BACH1 | activates | R-2749 | 11 | 3 | Drugs (5) |
| CMF-04570 | LAMC3 | down-regulates | IKZF1 | activates | R-3138 | 16 | 5 | Drugs (5) |
| CMF-04678 | RUSC2 | down-regulates | ATF5 | activates | R-365 | 14 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-04928 | ABCC5 | down-regulates | TEAD3 | activates | R-2107 | 15 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-04971 | ABCC5 | down-regulates | BACH1 | activates | R-2749 | 11 | 4 | Drugs (5) |
| CMF-05002 | ODZ4 | down-regulates | BACH1 | activates | R-2749 | 11 | 4 | Drugs (5) |
| CMF-05023 | NUP210L | down-regulates | ATF5 | activates | R-365 | 14 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-05765 | ADAMTS19 | down-regulates | ATF5 | activates | R-365 | 14 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-05791 | ADAMTS19 | down-regulates | PLAG1 | activates | R-2512 | 5 | 3 | Drugs (2) |
| CMF-06529 | SETD2 | down-regulates | IKZF1 | activates | R-3138 | 16 | 2 | Drugs (5) |
| CMF-06668 | ATRX | down-regulates | STAT3 | activates | R-1530 | 25 | 17 | Drugs (5) |
| CMF-06770 | ATRX | down-regulates | LEF1 | activates | R-1425 | 18 | 12 | Drugs (2) |
| CMF-06871 | ATRX | down-regulates | TEAD3 | activates | R-2107 | 15 | 13 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-07814 | TNK2 | down-regulates | TEAD4 | activates | R-3366 | 6 | 2 | Drugs (5) |
| CMF-08290 | KIF4A | down-regulates | IKZF1 | activates | R-3138 | 16 | 4 | Drugs (5) |
| CMF-08573 | FOXR2 | down-regulates | STAT3 | activates | R-1530 | 25 | 6 | Drugs (5) |
| CMF-08580 | FOXR2 | down-regulates | TEAD4 | activates | R-3366 | 6 | 3 | Drugs (5) |
| CMF-08705 | MYH14 | up-regulates | KLF4 | activates | R-2122 | 10 | 1 | Drugs (2) |
| CMF-09023 | NALCN | down-regulates | JUN | activates | R-231 | 25 | 7 | Drugs (2) |
| CMF-09250 | RP1 | down-regulates | TEAD4 | activates | R-3366 | 6 | 3 | Drugs (5) |
| CMF-09290 | RP1 | down-regulates | PLAG1 | activates | R-2512 | 5 | 3 | Drugs (2) |
| CMF-10070 | ATP8A2 | down-regulates | IKZF1 | activates | R-3138 | 16 | 3 | Drugs (5) |
| CMF-10226 | SEMG1 | down-regulates | ATF5 | activates | R-365 | 14 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-10789 | HELZ | up-regulates | STAT3 | activates | R-1530 | 25 | 2 | Drugs (5) |
| CMF-10888 | SMARCA2 | up-regulates | IKZF1 | activates | R-3138 | 16 | 3 | Drugs (5) |
| CMF-11308 | RPTN | up-regulates | TEAD3 | activates | R-2107 | 15 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-11385 | CYP4F22 | up-regulates | STAT3 | activates | R-1530 | 25 | 6 | Drugs (5) |
| CMF-11394 | CYP4F22 | up-regulates | TP53 | activates | R-1776 | 13 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-11424 | CYP4F22 | up-regulates | IKZF1 | activates | R-3138 | 16 | 5 | Drugs (5) |
| CMF-11540 | PREX2 | up-regulates | TP53 | activates | R-1776 | 13 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-11633 | CHSY3 | down-regulates | BACH1 | activates | R-2749 | 11 | 3 | Drugs (5) |
| CMF-12199 | GPR98 | down-regulates | STAT3 | activates | R-1530 | 25 | 9 | Drugs (5) |
| CMF-12319 | GPR98 | down-regulates | IKZF1 | activates | R-3138 | 16 | 9 | Drugs (5) |
| CMF-12369 | GPR98 | down-regulates | BACH1 | activates | R-2749 | 11 | 7 | Drugs (5) |
| CMF-12374 | GPR98 | up-regulates | HOXD13 | represses | R-3758 | 1 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-12377 | GPR98 | down-regulates | PLAG1 | activates | R-2512 | 5 | 3 | Drugs (2) |
| CMF-12620 | SLCO6A1 | down-regulates | BACH1 | activates | R-2749 | 11 | 1 | Drugs (5) |
| CMF-13347 | FMN1 | up-regulates | STAT3 | activates | R-1530 | 25 | 6 | Drugs (5) |
| CMF-13419 | FMN1 | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-13712 | KEL | up-regulates | TBX1 | represses | R-2241 | 9 | 2 | Drugs (2) |
| CMF-13768 | ADAMTS8 | down-regulates | LEF1 | activates | R-1425 | 18 | 4 | Drugs (2) |
| CMF-14038 | CEACAM20 | down-regulates | IKZF1 | activates | R-3138 | 16 | 2 | Drugs (5) |
| CMF-14348 | SIPA1L1 | down-regulates | TEAD4 | activates | R-3366 | 6 | 2 | Drugs (5) |
| CMF-14372 | ST18 | down-regulates | TEAD3 | activates | R-2107 | 15 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-14986 | XK | down-regulates | KLF4 | activates | R-2122 | 10 | 2 | Drugs (2) |
| CMF-15240 | HCN1 | up-regulates | STAT3 | activates | R-1530 | 25 | 4 | Drugs (5) |
| CMF-15253 | HCN1 | up-regulates | LEF1 | activates | R-1425 | 18 | 3 | Drugs (2) |
| CMF-15288 | HCN1 | up-regulates | NFAT5 | activates | R-3668 | 4 | 2 | Drugs (5) |
| CMF-15636 | DCHS2 | up-regulates | TEAD3 | activates | R-2107 | 15 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-15649 | DCHS2 | up-regulates | JUN | activates | R-231 | 25 | 9 | Drugs (2) |
| CMF-16212 | USP11 | down-regulates | TEAD3 | activates | R-2107 | 15 | 8 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-16422 | SUSD5 | up-regulates | TEAD3 | activates | R-2107 | 15 | 8 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-16765 | MACF1 | down-regulates | STAT3 | activates | R-1530 | 25 | 4 | Drugs (5) |
| CMF-16864 | OR5I1 | down-regulates | IKZF1 | activates | R-3138 | 16 | 4 | Drugs (5) |
| CMF-16896 | TIE1 | up-regulates | TEAD4 | activates | R-3366 | 6 | 1 | Drugs (5) |
| CMF-17146 | CDH18 | up-regulates | ATF5 | activates | R-365 | 14 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-17545 | CNTNAP3 | up-regulates | IKZF1 | activates | R-3138 | 16 | 3 | Drugs (5) |
| CMF-17591 | ODZ1 | down-regulates | TP53 | activates | R-1776 | 13 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-17977 | PRPF40B | down-regulates | ATF5 | activates | R-365 | 14 | 10 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-18061 | PRPF40B | down-regulates | BACH1 | activates | R-2749 | 11 | 4 | Drugs (5) |
| CMF-18461 | LAMA1 | up-regulates | TEAD3 | activates | R-2107 | 15 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-18694 | MPP7 | down-regulates | LEF1 | activates | R-1425 | 18 | 2 | Drugs (2) |
| CMF-19178 | PTPRR | up-regulates | KLF4 | activates | R-2122 | 10 | 2 | Drugs (2) |
| CMF-19295 | NF1 | up-regulates | ATF5 | activates | R-365 | 14 | 11 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-19341 | NF1 | up-regulates | TEAD3 | activates | R-2107 | 15 | 11 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-19355 | NF1 | up-regulates | JUN | activates | R-231 | 25 | 16 | Drugs (2) |
| CMF-19441 | NF1 | up-regulates | NFAT5 | activates | R-3668 | 4 | 3 | Drugs (5) |
| CMF-19508 | NF1 | up-regulates | KLF4 | activates | R-2122 | 10 | 6 | Drugs (2) |
| CMF-19578 | NF1 | up-regulates | BACH1 | activates | R-2749 | 11 | 8 | Drugs (5) |
| CMF-19598 | NF1 | up-regulates | PLAG1 | activates | R-2512 | 5 | 4 | Drugs (2) |
| CMF-19663 | RPSAP58 | up-regulates | IKZF1 | activates | R-3138 | 16 | 8 | Drugs (5) |
| CMF-20033 | ARHGEF16 | down-regulates | TEAD4 | activates | R-3366 | 6 | 1 | Drugs (5) |
| CMF-20357 | CUX2 | up-regulates | STAT3 | activates | R-1530 | 25 | 8 | Drugs (5) |
| CMF-20472 | CUX2 | down-regulates | HOXD13 | represses | R-3758 | 1 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-20961 | KLHL13 | up-regulates | BACH1 | activates | R-2749 | 11 | 2 | Drugs (5) |
| CMF-21051 | KRTAP4-7 | up-regulates | TEAD3 | activates | R-2107 | 15 | 10 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-21102 | KRTAP4-7 | up-regulates | BACH1 | activates | R-2749 | 11 | 7 | Drugs (5) |
| CMF-21113 | KRTAP4-7 | down-regulates | TBX1 | represses | R-2241 | 9 | 2 | Drugs (2) |
| CMF-21180 | ATM | up-regulates | TEAD3 | activates | R-2107 | 15 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-22166 | PDGFRA | down-regulates | KLF4 | activates | R-2122 | 10 | 7 | Drugs (2) |
| CMF-22260 | IDH1 | down-regulates | STAT3 | activates | R-1530 | 25 | 19 | Drugs (5) |
| CMF-22394 | IDH1 | down-regulates | LEF1 | activates | R-1425 | 18 | 13 | Drugs (2) |
| CMF-22524 | IDH1 | down-regulates | TEAD3 | activates | R-2107 | 15 | 15 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-24375 | SMCHD1 | down-regulates | TBX1 | represses | R-2241 | 9 | 1 | Drugs (2) |
| CMF-24590 | THADA | down-regulates | LEF1 | activates | R-1425 | 18 | 2 | Drugs (2) |
| CMF-24609 | THADA | down-regulates | KLF4 | activates | R-2122 | 10 | 6 | Drugs (2) |
| CMF-25180 | ABCA9 | down-regulates | PLAG1 | activates | R-2512 | 5 | 1 | Drugs (2) |
| CMF-25354 | PARG | down-regulates | PLAG1 | activates | R-2512 | 5 | 1 | Drugs (2) |
| CMF-25497 | CCDC85A | down-regulates | JUN | activates | R-231 | 25 | 2 | Drugs (2) |
| CMF-26444 | SPAG5 | down-regulates | TBX1 | represses | R-2241 | 9 | 1 | Drugs (2) |
| CMF-26547 | AADACL4 | up-regulates | HOXD13 | represses | R-3758 | 1 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-26723 | ITGA10 | down-regulates | PLAG1 | activates | R-2512 | 5 | 1 | Drugs (2) |
| CMF-26791 | ANK1 | up-regulates | JUN | activates | R-231 | 25 | 2 | Drugs (2) |
| CMF-27380 | FGD5 | down-regulates | BACH1 | activates | R-2749 | 11 | 3 | Drugs (5) |
| CMF-28208 | REPIN1 | up-regulates | ATF3 | activates | R-467 | 5 | 3 | Drugs (5) |
| CMF-28297 | KRTAP4-8 | down-regulates | PLAG1 | activates | R-2512 | 5 | 1 | Drugs (2) |
| CMF-28393 | MYO9B | down-regulates | ATF3 | activates | R-467 | 5 | 2 | Drugs (5) |
| CMF-28399 | MYO9B | down-regulates | LEF1 | activates | R-1425 | 18 | 6 | Drugs (2) |
| CMF-28456 | MYO9B | down-regulates | PLAG1 | activates | R-2512 | 5 | 4 | Drugs (2) |
| CMF-28672 | PCNX | up-regulates | HOXD13 | represses | R-3758 | 1 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-29171 | AQP10 | down-regulates | ATF3 | activates | R-467 | 5 | 2 | Drugs (5) |
| CMF-29233 | AQP10 | down-regulates | KLF4 | activates | R-2122 | 10 | 5 | Drugs (2) |
| CMF-29251 | AQP10 | down-regulates | BACH1 | activates | R-2749 | 11 | 5 | Drugs (5) |
| CMF-29490 | SEMA3E | up-regulates | JUN | activates | R-231 | 25 | 7 | Drugs (2) |
| CMF-29507 | SEMA3E | up-regulates | NFAT5 | activates | R-3668 | 4 | 2 | Drugs (5) |
| CMF-29829 | ABCC9 | up-regulates | STAT3 | activates | R-1530 | 25 | 6 | Drugs (5) |
| CMF-29851 | ABCC9 | up-regulates | ATF3 | activates | R-467 | 5 | 3 | Drugs (5) |
| CMF-29862 | ABCC9 | up-regulates | TEAD3 | activates | R-2107 | 15 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-29867 | ABCC9 | up-regulates | JUN | activates | R-231 | 25 | 8 | Drugs (2) |
| CMF-30150 | MKI67 | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-30463 | PROKR2 | down-regulates | TEAD4 | activates | R-3366 | 6 | 3 | Drugs (5) |
| CMF-30601 | SALL4 | down-regulates | TEAD4 | activates | R-3366 | 6 | 2 | Drugs (5) |
| CMF-31014 | ZNF676 | up-regulates | STAT3 | activates | R-1530 | 25 | 3 | Drugs (5) |
| CMF-31210 | ACACA | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-34827 | NUP210L | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 20 | Drugs (5) |
| CMF-34828 | NUP210L | up-regulates | hsa-mir-9 | represses | R-3138 | 25 | 20 | Drugs (5) |
| CMF-34830 | NUP210L | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 20 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-34963 | ADAMTS19 | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 2 | Drugs (5) |
| CMF-35159 | AFF2 | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 3 | Drugs (5) |
| CMF-35160 | AFF2 | up-regulates | hsa-mir-9 | represses | R-3138 | 25 | 3 | Drugs (5) |
| CMF-35582 | ATRX | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 25 | Drugs (5) |
| CMF-35583 | ATRX | up-regulates | hsa-mir-9 | represses | R-3138 | 25 | 25 | Drugs (5) |
| CMF-35585 | ATRX | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 25 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-38003 | XK | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 3 | Drugs (5) |
| CMF-38005 | XK | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-38348 | ZNF845 | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-38638 | OR5I1 | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 20 | Drugs (5) |
| CMF-38639 | OR5I1 | up-regulates | hsa-mir-9 | represses | R-3138 | 25 | 20 | Drugs (5) |
| CMF-38641 | OR5I1 | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 20 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-38881 | DYNC1I1 | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 1 | Drugs (5) |
| CMF-39657 | NF1 | down-regulates | hsa-mir-9 | represses | R-467 | 25 | 10 | Drugs (5) |
| CMF-39658 | NF1 | down-regulates | hsa-mir-9 | represses | R-3138 | 25 | 10 | Drugs (5) |
| CMF-39660 | NF1 | down-regulates | hsa-mir-9 | represses | R-3758 | 25 | 10 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-39996 | ATN1 | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 3 | Drugs (5) |
| CMF-39997 | ATN1 | up-regulates | hsa-mir-9 | represses | R-3138 | 25 | 3 | Drugs (5) |
| CMF-39998 | ATN1 | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-40418 | PDGFRA | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 7 | Drugs (5) |
| CMF-40419 | PDGFRA | up-regulates | hsa-mir-9 | represses | R-3138 | 25 | 7 | Drugs (5) |
| CMF-40421 | PDGFRA | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-40872 | IDH1 | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 25 | Drugs (5) |
| CMF-40873 | IDH1 | up-regulates | hsa-mir-9 | represses | R-3138 | 25 | 25 | Drugs (5) |
| CMF-40875 | IDH1 | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 25 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-41881 | IQSEC3 | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 17 | Drugs (5) |
| CMF-41882 | IQSEC3 | up-regulates | hsa-mir-9 | represses | R-3138 | 25 | 17 | Drugs (5) |
| CMF-41884 | IQSEC3 | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 17 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-42138 | AADACL4 | up-regulates | hsa-mir-9 | represses | R-3138 | 25 | 3 | Drugs (5) |
| CMF-42140 | AADACL4 | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-42404 | CXorf57 | up-regulates | hsa-mir-9 | represses | R-467 | 25 | 4 | Drugs (5) |
| CMF-42405 | CXorf57 | up-regulates | hsa-mir-9 | represses | R-3138 | 25 | 4 | Drugs (5) |
| CMF-42407 | CXorf57 | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-42721 | SIPA1L2 | up-regulates | hsa-mir-9 | represses | R-3758 | 25 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-31225 | SHP2_SIGNALING | up-regulates | TP53 | activates | R-1776 | 13 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-31442 | SIGNALING_EVENTS_MEDIATED_BY_TCPTP | up-regulates | TP53 | activates | R-1776 | 13 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-31512 | EGF_RECEPTOR_SIGNALING_PATHWAY | up-regulates | TP53 | activates | R-1776 | 13 | 6 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-31518 | EGF_RECEPTOR_SIGNALING_PATHWAY | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-32072 | A6B1_AND_A6B4_INTEGRIN_SIGNALING | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-32090 | A6B1_AND_A6B4_INTEGRIN_SIGNALING | up-regulates | TEAD3 | activates | R-2107 | 15 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-32780 | E_CADHERIN_SIGNALING_IN_KERATINOCYTES | up-regulates | TP53 | activates | R-1776 | 13 | 7 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-32785 | E_CADHERIN_SIGNALING_IN_KERATINOCYTES | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-32795 | E_CADHERIN_SIGNALING_IN_KERATINOCYTES | up-regulates | TEAD3 | activates | R-2107 | 15 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-33232 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | TEAD3 | activates | R-2107 | 15 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-33302 | ERBB1_DOWNSTREAM_SIGNALING | up-regulates | TP53 | activates | R-1776 | 13 | 7 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-33308 | ERBB1_DOWNSTREAM_SIGNALING | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-33789 | SIGNALING_EVENTS_MEDIATED_BY_PTP1B | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |