Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation SPEF2_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-03000 | SPEF2 | up-regulates | ZNF652 | activates | R-3645 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03004 | SPEF2 | up-regulates | BPTF | represses | R-2879 | 21 | 3 | Drugs (2) |
| CMF-03007 | SPEF2 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-03008 | SPEF2 | down-regulates | ELF4 | activates | R-3017 | 20 | 1 | Drugs (4) |
| CMF-03016 | SPEF2 | down-regulates | STAT6 | activates | R-2280 | 11 | 1 | Drugs (2) |
| CMF-34361 | SPEF2 | up-regulates | hsa-mir-20b | represses | R-117 | 44 | 3 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-34362 | SPEF2 | up-regulates | hsa-mir-20b | represses | R-397 | 44 | 3 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-34363 | SPEF2 | up-regulates | hsa-mir-20b | represses | R-2477 | 44 | 3 | Drugs (2) |