Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation PLAC1L_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-41040 | PLAC1L | down-regulates | hsa-mir-636 | represses | R-1598 | 1 | 1 | Drugs (52) Regulator Drugs (0)Regulon Drugs (52)TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988 |