Causal Flows
are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators
and regulons
. In the causal flow, a mutation
may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation PCDH7_code_potential_somatic
ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
---|---|---|---|---|---|---|---|---|
CMF-12116 | PCDH7 | down-regulates | ALX4 | represses | R-2914 | 20 | 1 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
CMF-12117 | PCDH7 | down-regulates | LMX1B | represses | R-2929 | 11 | 1 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
CMF-12118 | PCDH7 | down-regulates | STAT4 | represses | R-1156 | 16 | 1 | Drugs (1) |