Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation MSR1_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-30279 | MSR1 | up-regulates | HSF1 | activates | R-96 | 4 | 1 | Drugs (1) |
| CMF-30280 | MSR1 | up-regulates | NR2E1 | activates | R-2391 | 9 | 1 | Drugs (1) |
| CMF-30290 | MSR1 | up-regulates | FOXJ3 | activates | R-1166 | 23 | 4 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-30293 | MSR1 | up-regulates | FOXJ3 | activates | R-1167 | 23 | 4 | Drugs (2) |
| CMF-30299 | MSR1 | up-regulates | IRF3 | activates | R-2441 | 25 | 1 | Drugs (2) |
| CMF-30300 | MSR1 | down-regulates | WT1 | represses | R-1398 | 4 | 1 | Drugs (2) |
| CMF-30301 | MSR1 | up-regulates | CEBPG | activates | R-1047 | 23 | 1 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN |
| CMF-30303 | MSR1 | up-regulates | FOXJ2 | activates | R-723 | 17 | 5 | Drugs (2) |
| CMF-30310 | MSR1 | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-30312 | MSR1 | up-regulates | SOX11 | activates | R-851 | 19 | 2 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)AMG-780, MEDI-3617, ENIBARCIMAB, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-30317 | MSR1 | up-regulates | ZNF148 | activates | R-825 | 23 | 4 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |