List of causal flows influenced by the mutation.
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation LRP1_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-18571 | LRP1 | down-regulates | GLI3 | activates | R-3386 | 6 | 2 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)PAZOPANIB, PEMIGATINIB, BRIVANIB ALANINATE, ERDAFITINIB, HMPL-453, PAZOPANIB HYDROCHLORIDE, BRIVANIB, NINTEDANIB ESYLATE, XL-999, DOVITINIB, ROGARATINIB, AZD-4547, ENMD-2076, INFIGRATINIB, FGFR INHIBITOR DEBIO 1347, INFIGRATINIB PHOSPHATE, NINTEDANIB, FUTIBATINIB, MASITINIB, ORANTINIB, DERAZANTINIB, E-7090, ENMD-981693 |