Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation ITGAM_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-29268 | ITGAM | down-regulates | IKZF1 | activates | R-3133 | 16 | 1 | Drugs (1) |
| CMF-29269 | ITGAM | up-regulates | MYCN | represses | R-1806 | 5 | 1 | Drugs (2) |
| CMF-42828 | ITGAM | up-regulates | hsa-mir-454-3p | represses | R-371 | 31 | 1 | Drugs (31) Regulator Drugs (0)Regulon Drugs (31)RILAPLADIB, CALCIFEDIOL, BECOCALCIDIOL, TACROLIMUS, INTERFERON GAMMA-1B, TEMSIROLIMUS, PARICALCITOL, INECALCITOL, BATOCLIMAB, ERGOCALCIFEROL, CHOLECALCIFEROL, NIPOCALIMAB, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, EVEROLIMUS, DARAPLADIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SIROLIMUS, EFGARTIGIMOD ALFA, SEOCALCITOL, ROZANOLIXIZUMAB, VERNAKALANT, PEFCALCITOL, VERNAKALANT HYDROCHLORIDE, LUNACALCIPOL, PIMECROLIMUS, DP001, ALFACALCIDOL |
| CMF-42829 | ITGAM | up-regulates | hsa-mir-10b | represses | R-2053 | 14 | 1 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |