List of causal flows influenced by the mutation.
Causal Flows
are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators
and regulons
. In the causal flow, a mutation
may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation FNDC3B_code_potential_somatic
ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
---|---|---|---|---|---|---|---|---|
CMF-11587 | FNDC3B | down-regulates | LHX3 | represses | R-2002 | 24 | 1 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
CMF-11588 | FNDC3B | down-regulates | FOXD2 | represses | R-2583 | 6 | 2 | Drugs (1) |
CMF-37235 | FNDC3B | up-regulates | hsa-mir-149 | represses | R-2836 | 51 | 1 | Drugs (4) |