Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation CSPG4_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-39991 | CSPG4 | down-regulates | hsa-mir-328 | represses | R-1047 | 27 | 3 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN |
| CMF-39992 | CSPG4 | down-regulates | hsa-mir-328 | represses | R-1734 | 27 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-39993 | CSPG4 | down-regulates | hsa-mir-328 | represses | R-3789 | 27 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |