Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation CHL1_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-37372 | CHL1 | down-regulates | hsa-mir-338 | represses | R-1734 | 79 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-37373 | CHL1 | down-regulates | hsa-mir-338 | represses | R-3789 | 79 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-37374 | CHL1 | down-regulates | hsa-mir-338 | represses | R-2043 | 79 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |