Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
YME1L1 - YME1 like 1 ATPase
Function
ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 10730 | ENSG00000136758 | YME1L1 | Q96TA2 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1071 | Pr-149 | 1 | 1 | 4 |
| R-1147 | Pr-58 | 1 | 1 | 12 |
| R-1162 | Pr-149 | 1 | 1 | 14 |
| R-1167 | Pr-58 | 1 | 1 | 6 |
| R-1270 | Pr-148 | 1 | 1 | 2 |
| R-1466 | Pr-144 | 1 | 1 | 4 |
| R-1474 | Pr-58 | 1 | 1 | 7 |
| R-1600 | Pr-58 | 1 | 1 | 7 |
| R-1632 | Pr-58 | 1 | 1 | 9 |
| R-1682 | Pr-58 | 1 | 1 | 17 |
| R-1792 | Pr-58 | 1 | 1 | 1 |
| R-2033 | Pr-144 | 1 | 1 | 7 |
| R-2253 | Pr-58 | 1 | 1 | 7 |
| R-2891 | Pr-58 | 1 | 1 | 5 |
| R-3190 | Pr-144 | 1 | 1 | 2 |
| R-3225 | Pr-58 | 1 | 1 | 4 |
| R-3462 | Pr-58 | 1 | 1 | 12 |
| R-3622 | Pr-144 | 1 | 1 | 9 |
| R-701 | Pr-149 | 1 | 1 | 5 |
| R-723 | Pr-58 | 1 | 1 | 14 |