Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
TRIO - trio Rho guanine nucleotide exchange factor
Function
Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:22155786, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 7204 | ENSG00000038382 | TRIO | O75962 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1011 | Pr-38 | 1 | 1 | 22 |
| R-1099 | Pr-38 | 1 | 1 | 11 |
| R-1239 | Pr-38 | 1 | 1 | 25 |
| R-1462 | Pr-38 | 1 | 1 | 3 |
| R-1590 | Pr-38 | 1 | 1 | 22 |
| R-1611 | Pr-38 | 1 | 1 | 6 |
| R-1736 | Pr-38 | 1 | 1 | 2 |
| R-1830 | Pr-38 | 1 | 1 | 16 |
| R-1884 | Pr-38 | 1 | 1 | 7 |
| R-1938 | Pr-38 | 1 | 1 | 36 |
| R-1950 | Pr-43 | 1 | 1 | 45 |
| R-2032 | Pr-38 | 1 | 1 | 54 |
| R-2384 | Pr-38 | 1 | 1 | 16 |
| R-2416 | Pr-38 | 1 | 1 | 5 |
| R-2453 | Pr-38 | 1 | 1 | 20 |
| R-2737 | Pr-38 | 1 | 1 | 42 |
| R-2768 | Pr-38 | 1 | 1 | 6 |
| R-2801 | Pr-38 | 1 | 1 | 5 |
| R-2828 | Pr-38 | 1 | 1 | 17 |
| R-2861 | Pr-38 | 1 | 1 | 31 |
| R-2884 | Pr-38 | 1 | 1 | 33 |
| R-2944 | Pr-38 | 1 | 1 | 16 |
| R-462 | Pr-38 | 1 | 1 | 24 |
| R-625 | Pr-38 | 1 | 1 | 5 |
| R-698 | Pr-38 | 1 | 1 | 26 |
| R-759 | Pr-38 | 1 | 1 | 30 |
| R-767 | Pr-38 | 1 | 1 | 3 |
| R-993 | Pr-38 | 1 | 1 | 31 |