Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
TRADD - TNFRSF1A associated via death domain
Function
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (PubMed:7758105, PubMed:8612133, PubMed:23955153). Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (PubMed:7758105, PubMed:8612133). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 8717 | ENSG00000102871 | TRADD | Q15628 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-114 | Pr-0 | 1 | 1 | 12 |
| R-1300 | Pr-0 | 1 | 1 | 25 |
| R-175 | Pr-0 | 1 | 1 | 11 |
| R-1806 | Pr-133 | 1 | 1 | 21 |
| R-1813 | Pr-0 | 1 | 1 | 2 |
| R-2113 | Pr-0 | 1 | 1 | 5 |
| R-2348 | Pr-0 | 1 | 1 | 9 |
| R-2452 | Pr-0 | 1 | 1 | 3 |
| R-2498 | Pr-0 | 1 | 1 | 17 |
| R-2589 | Pr-0 | 1 | 1 | 4 |
| R-2687 | Pr-0 | 1 | 1 | 14 |
| R-276 | Pr-0 | 1 | 1 | 13 |
| R-2863 | Pr-0 | 1 | 1 | 2 |
| R-3090 | Pr-0 | 1 | 1 | 6 |
| R-3096 | Pr-133 | 1 | 1 | 9 |
| R-3103 | Pr-0 | 1 | 1 | 9 |
| R-3120 | Pr-0 | 1 | 1 | 8 |
| R-375 | Pr-0 | 1 | 1 | 9 |
| R-445 | Pr-0 | 1 | 1 | 15 |
| R-648 | Pr-0 | 1 | 1 | 7 |
| R-848 | Pr-0 | 1 | 1 | 9 |
| R-991 | Pr-0 | 1 | 1 | 7 |