Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
SERPINE1 - serpin family E member 1
Function
Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 5054 | ENSG00000106366 | SERPINE1 | P05121 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1073 | Pr-1 | 1 | 1 | 4 |
| R-1133 | Pr-1 | 1 | 1 | 8 |
| R-1170 | Pr-1 | 1 | 1 | 4 |
| R-1308 | Pr-1 | 1 | 1 | 10 |
| R-1346 | Pr-1 | 1 | 1 | 12 |
| R-1495 | Pr-1 | 1 | 1 | 7 |
| R-157 | Pr-28 | 1 | 1 | 19 |
| R-1651 | Pr-1 | 1 | 1 | 3 |
| R-1886 | Pr-1 | 1 | 1 | 5 |
| R-1895 | Pr-28 | 1 | 1 | 7 |
| R-1912 | Pr-1 | 1 | 1 | 8 |
| R-2053 | Pr-1 | 1 | 1 | 61 |
| R-2268 | Pr-1 | 1 | 1 | 5 |
| R-2322 | Pr-1 | 1 | 1 | 6 |
| R-2331 | Pr-28 | 1 | 1 | 6 |
| R-2364 | Pr-1 | 1 | 1 | 5 |
| R-2438 | Pr-1 | 1 | 1 | 14 |
| R-245 | Pr-28 | 1 | 1 | 30 |
| R-2543 | Pr-1 | 1 | 1 | 7 |
| R-2601 | Pr-28 | 1 | 1 | 13 |
| R-2612 | Pr-1 | 1 | 1 | 8 |
| R-2620 | Pr-1 | 1 | 1 | 3 |
| R-2705 | Pr-9 | 1 | 1 | 14 |
| R-2762 | Pr-1 | 1 | 1 | 15 |
| R-2765 | Pr-28 | 1 | 1 | 15 |
| R-2781 | Pr-28 | 1 | 1 | 10 |
| R-2954 | Pr-1 | 1 | 1 | 14 |
| R-3016 | Pr-1 | 1 | 1 | 21 |
| R-3029 | Pr-28 | 1 | 1 | 20 |
| R-3037 | Pr-1 | 1 | 1 | 5 |
| R-3066 | Pr-1 | 1 | 1 | 6 |
| R-3107 | Pr-1 | 1 | 1 | 5 |
| R-3131 | Pr-28 | 1 | 1 | 11 |
| R-3264 | Pr-1 | 1 | 1 | 5 |
| R-3379 | Pr-1 | 1 | 1 | 5 |
| R-3552 | Pr-1 | 1 | 1 | 6 |
| R-3563 | Pr-1 | 1 | 1 | 3 |
| R-3571 | Pr-28 | 1 | 1 | 9 |
| R-3603 | Pr-9 | 1 | 1 | 34 |
| R-385 | Pr-1 | 1 | 1 | 15 |
| R-582 | Pr-1 | 1 | 1 | 6 |
| R-632 | Pr-1 | 1 | 1 | 10 |
| R-646 | Pr-140 | 1 | 1 | 51 |
| R-980 | Pr-1 | 1 | 1 | 6 |