Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
SBNO2 - strawberry notch homolog 2
Function
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the pro-inflammatory cascade (PubMed:18025162).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 22904 | ENSG00000278788 | SBNO2 | Q9Y2G9 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1306 | Pr-12 | 1 | 1 | 12 |
| R-1381 | Pr-12 | 1 | 1 | 13 |
| R-1484 | Pr-155 | 1 | 1 | 17 |
| R-211 | Pr-155 | 1 | 1 | 20 |
| R-2346 | Pr-155 | 1 | 1 | 14 |
| R-2451 | Pr-131 | 1 | 1 | 68 |
| R-2475 | Pr-155 | 1 | 1 | 10 |
| R-2508 | Pr-155 | 1 | 1 | 7 |
| R-2538 | Pr-155 | 1 | 1 | 9 |
| R-2830 | Pr-12 | 1 | 1 | 69 |
| R-2864 | Pr-12 | 1 | 1 | 62 |
| R-3033 | Pr-12 | 1 | 1 | 92 |
| R-3180 | Pr-12 | 1 | 1 | 74 |
| R-373 | Pr-155 | 1 | 1 | 12 |
| R-553 | Pr-12 | 1 | 1 | 3 |
| R-61 | Pr-12 | 1 | 1 | 55 |
| R-651 | Pr-12 | 1 | 1 | 76 |
| R-996 | Pr-155 | 1 | 1 | 13 |