Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
PTPN12 - protein tyrosine phosphatase non-receptor type 12
Function
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 5782 | ENSG00000127947 | PTPN12 | Q05209 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1037 | Pr-131 | 1 | 1 | 7 |
| R-113 | Pr-138 | 1 | 1 | 10 |
| R-1304 | Pr-131 | 1 | 1 | 22 |
| R-1448 | Pr-131 | 1 | 1 | 1 |
| R-1645 | Pr-131 | 1 | 1 | 57 |
| R-1699 | Pr-131 | 1 | 1 | 18 |
| R-177 | Pr-131 | 1 | 1 | 55 |
| R-194 | Pr-131 | 1 | 1 | 5 |
| R-235 | Pr-131 | 1 | 1 | 7 |
| R-2622 | Pr-131 | 1 | 1 | 35 |
| R-2671 | Pr-131 | 1 | 1 | 7 |
| R-3008 | Pr-131 | 1 | 1 | 14 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-377 | Pr-131 | 1 | 1 | 22 |
| R-415 | Pr-131 | 1 | 1 | 39 |
| R-626 | Pr-131 | 1 | 1 | 52 |
| R-738 | Pr-131 | 1 | 1 | 45 |
| R-970 | Pr-131 | 1 | 1 | 56 |
| R-995 | Pr-131 | 1 | 1 | 19 |