Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
OTUD4 - OTU deubiquitinase 4
Function
Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 54726 | ENSG00000164164 | OTUD4 | Q01804 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1036 | Pr-38 | 1 | 1 | 9 |
| R-1099 | Pr-38 | 1 | 1 | 11 |
| R-1144 | Pr-38 | 1 | 1 | 19 |
| R-1301 | Pr-38 | 1 | 1 | 38 |
| R-159 | Pr-38 | 1 | 1 | 11 |
| R-1590 | Pr-38 | 1 | 1 | 22 |
| R-1772 | Pr-38 | 1 | 1 | 26 |
| R-1830 | Pr-38 | 1 | 1 | 16 |
| R-1938 | Pr-38 | 1 | 1 | 36 |
| R-1944 | Pr-38 | 1 | 1 | 32 |
| R-1950 | Pr-43 | 1 | 1 | 45 |
| R-2021 | Pr-38 | 1 | 1 | 69 |
| R-2125 | Pr-38 | 1 | 1 | 27 |
| R-2370 | Pr-38 | 1 | 1 | 1 |
| R-2394 | Pr-38 | 1 | 1 | 28 |
| R-2453 | Pr-38 | 1 | 1 | 20 |
| R-2655 | Pr-38 | 1 | 1 | 5 |
| R-2670 | Pr-38 | 1 | 1 | 36 |
| R-2685 | Pr-38 | 1 | 1 | 42 |
| R-2807 | Pr-38 | 1 | 1 | 5 |
| R-2884 | Pr-38 | 1 | 1 | 33 |
| R-2944 | Pr-38 | 1 | 1 | 16 |
| R-625 | Pr-38 | 1 | 1 | 5 |
| R-698 | Pr-38 | 1 | 1 | 26 |
| R-767 | Pr-38 | 1 | 1 | 3 |
| R-968 | Pr-38 | 1 | 1 | 22 |
| R-993 | Pr-38 | 1 | 1 | 31 |