Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
FHL2 - four and a half LIM domains 2
Function
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 2274 | ENSG00000115641 | FHL2 | Q14192 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1046 | Pr-1 | 1 | 1 | 2 |
| R-1073 | Pr-1 | 1 | 1 | 4 |
| R-1133 | Pr-1 | 1 | 1 | 8 |
| R-1170 | Pr-1 | 1 | 1 | 4 |
| R-12 | Pr-1 | 1 | 1 | 14 |
| R-1308 | Pr-1 | 1 | 1 | 10 |
| R-1495 | Pr-1 | 1 | 1 | 7 |
| R-1651 | Pr-1 | 1 | 1 | 3 |
| R-167 | Pr-1 | 1 | 1 | 10 |
| R-1886 | Pr-1 | 1 | 1 | 5 |
| R-1912 | Pr-1 | 1 | 1 | 8 |
| R-2005 | Pr-1 | 1 | 1 | 13 |
| R-2268 | Pr-1 | 1 | 1 | 5 |
| R-2438 | Pr-1 | 1 | 1 | 14 |
| R-2612 | Pr-1 | 1 | 1 | 8 |
| R-2620 | Pr-1 | 1 | 1 | 3 |
| R-2705 | Pr-9 | 1 | 1 | 14 |
| R-2762 | Pr-1 | 1 | 1 | 15 |
| R-2811 | Pr-1 | 1 | 1 | 5 |
| R-2954 | Pr-1 | 1 | 1 | 14 |
| R-3010 | Pr-142 | 1 | 1 | 59 |
| R-3016 | Pr-1 | 1 | 1 | 21 |
| R-3066 | Pr-1 | 1 | 1 | 6 |
| R-3107 | Pr-1 | 1 | 1 | 5 |
| R-3175 | Pr-142 | 1 | 1 | 10 |
| R-3264 | Pr-1 | 1 | 1 | 5 |
| R-3552 | Pr-1 | 1 | 1 | 6 |
| R-3563 | Pr-1 | 1 | 1 | 3 |
| R-362 | Pr-1 | 1 | 1 | 8 |
| R-385 | Pr-1 | 1 | 1 | 15 |
| R-572 | Pr-142 | 1 | 1 | 39 |
| R-582 | Pr-1 | 1 | 1 | 6 |
| R-632 | Pr-1 | 1 | 1 | 10 |
| R-646 | Pr-140 | 1 | 1 | 51 |
| R-683 | Pr-1 | 1 | 1 | 14 |
| R-856 | Pr-1 | 1 | 1 | 6 |
| R-980 | Pr-1 | 1 | 1 | 6 |