Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
DUSP6 - dual specificity phosphatase 6
Function
Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 1848 | ENSG00000139318 | DUSP6 | Q16828 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1099 | Pr-38 | 1 | 1 | 11 |
| R-1205 | Pr-38 | 1 | 1 | 21 |
| R-1301 | Pr-38 | 1 | 1 | 38 |
| R-1462 | Pr-38 | 1 | 1 | 3 |
| R-1551 | Pr-38 | 1 | 1 | 4 |
| R-159 | Pr-38 | 1 | 1 | 11 |
| R-1736 | Pr-38 | 1 | 1 | 2 |
| R-1772 | Pr-38 | 1 | 1 | 26 |
| R-1830 | Pr-38 | 1 | 1 | 16 |
| R-1873 | Pr-38 | 1 | 1 | 27 |
| R-1884 | Pr-38 | 1 | 1 | 7 |
| R-1950 | Pr-43 | 1 | 1 | 45 |
| R-1996 | Pr-38 | 1 | 1 | 39 |
| R-2021 | Pr-38 | 1 | 1 | 69 |
| R-2032 | Pr-38 | 1 | 1 | 54 |
| R-2125 | Pr-38 | 1 | 1 | 27 |
| R-2159 | Pr-38 | 1 | 1 | 32 |
| R-2685 | Pr-38 | 1 | 1 | 42 |
| R-2743 | Pr-38 | 1 | 1 | 17 |
| R-2756 | Pr-38 | 1 | 1 | 53 |
| R-2782 | Pr-38 | 1 | 1 | 64 |
| R-2807 | Pr-38 | 1 | 1 | 5 |
| R-2816 | Pr-38 | 1 | 1 | 20 |
| R-2843 | Pr-38 | 1 | 1 | 36 |
| R-2861 | Pr-38 | 1 | 1 | 31 |
| R-2884 | Pr-38 | 1 | 1 | 33 |
| R-2908 | Pr-38 | 1 | 1 | 36 |
| R-2927 | Pr-38 | 1 | 1 | 38 |
| R-2962 | Pr-38 | 1 | 1 | 52 |
| R-575 | Pr-38 | 1 | 1 | 39 |
| R-625 | Pr-38 | 1 | 1 | 5 |
| R-650 | Pr-38 | 1 | 1 | 36 |
| R-759 | Pr-38 | 1 | 1 | 30 |
| R-871 | Pr-38 | 1 | 1 | 25 |
| R-968 | Pr-38 | 1 | 1 | 22 |
| R-993 | Pr-38 | 1 | 1 | 31 |