Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
CSNK1A1 - casein kinase 1 alpha 1
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 1452 | ENSG00000113712 | CSNK1A1 | P48729 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-113 | Pr-138 | 1 | 1 | 10 |
| R-1448 | Pr-131 | 1 | 1 | 1 |
| R-1521 | Pr-131 | 1 | 1 | 20 |
| R-1645 | Pr-131 | 1 | 1 | 57 |
| R-1699 | Pr-131 | 1 | 1 | 18 |
| R-177 | Pr-131 | 1 | 1 | 55 |
| R-1853 | Pr-131 | 1 | 1 | 35 |
| R-1903 | Pr-131 | 1 | 1 | 9 |
| R-2145 | Pr-131 | 1 | 1 | 21 |
| R-235 | Pr-131 | 1 | 1 | 7 |
| R-2451 | Pr-131 | 1 | 1 | 68 |
| R-2609 | Pr-131 | 1 | 1 | 17 |
| R-2622 | Pr-131 | 1 | 1 | 35 |
| R-2841 | Pr-131 | 1 | 1 | 10 |
| R-2883 | Pr-131 | 1 | 1 | 29 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-3031 | Pr-131 | 1 | 1 | 36 |
| R-3072 | Pr-131 | 1 | 1 | 41 |
| R-3459 | Pr-131 | 1 | 1 | 56 |
| R-377 | Pr-131 | 1 | 1 | 22 |
| R-415 | Pr-131 | 1 | 1 | 39 |
| R-679 | Pr-131 | 1 | 1 | 63 |
| R-970 | Pr-131 | 1 | 1 | 56 |