Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
COLEC12 - collectin subfamily member 12
Function
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 81035 | ENSG00000158270 | COLEC12 | Q5KU26 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1005 | Pr-13 | 1 | 1 | 11 |
| R-112 | Pr-7 | 1 | 1 | 20 |
| R-123 | Pr-13 | 1 | 1 | 17 |
| R-137 | Pr-7 | 1 | 1 | 22 |
| R-1451 | Pr-13 | 1 | 1 | 5 |
| R-150 | Pr-13 | 1 | 1 | 9 |
| R-173 | Pr-7 | 1 | 1 | 34 |
| R-185 | Pr-13 | 1 | 1 | 16 |
| R-207 | Pr-7 | 1 | 1 | 44 |
| R-224 | Pr-13 | 1 | 1 | 15 |
| R-2454 | Pr-13 | 1 | 1 | 6 |
| R-254 | Pr-7 | 1 | 1 | 18 |
| R-2821 | Pr-13 | 1 | 1 | 6 |
| R-326 | Pr-7 | 1 | 1 | 29 |
| R-3698 | Pr-13 | 1 | 1 | 16 |
| R-370 | Pr-7 | 1 | 1 | 30 |
| R-395 | Pr-7 | 1 | 1 | 44 |
| R-406 | Pr-13 | 1 | 1 | 2 |
| R-413 | Pr-7 | 1 | 1 | 23 |
| R-431 | Pr-13 | 1 | 1 | 16 |
| R-457 | Pr-13 | 1 | 1 | 6 |
| R-709 | Pr-13 | 1 | 1 | 9 |