Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
CHST2 - carbohydrate sulfotransferase 2
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 9435 | ENSG00000175040 | CHST2 | Q9Y4C5 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1099 | Pr-38 | 1 | 1 | 11 |
| R-1210 | Pr-38 | 1 | 1 | 8 |
| R-1239 | Pr-38 | 1 | 1 | 25 |
| R-1301 | Pr-38 | 1 | 1 | 38 |
| R-159 | Pr-38 | 1 | 1 | 11 |
| R-1590 | Pr-38 | 1 | 1 | 22 |
| R-1736 | Pr-38 | 1 | 1 | 2 |
| R-2021 | Pr-38 | 1 | 1 | 69 |
| R-2159 | Pr-38 | 1 | 1 | 32 |
| R-2370 | Pr-38 | 1 | 1 | 1 |
| R-2499 | Pr-38 | 1 | 1 | 10 |
| R-2670 | Pr-38 | 1 | 1 | 36 |
| R-2685 | Pr-38 | 1 | 1 | 42 |
| R-2756 | Pr-38 | 1 | 1 | 53 |
| R-2782 | Pr-38 | 1 | 1 | 64 |
| R-2807 | Pr-38 | 1 | 1 | 5 |
| R-2908 | Pr-38 | 1 | 1 | 36 |
| R-575 | Pr-38 | 1 | 1 | 39 |
| R-625 | Pr-38 | 1 | 1 | 5 |
| R-698 | Pr-38 | 1 | 1 | 26 |
| R-767 | Pr-38 | 1 | 1 | 3 |
| R-871 | Pr-38 | 1 | 1 | 25 |
| R-993 | Pr-38 | 1 | 1 | 31 |