Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
CASP4 - caspase 4
Function
(Microbial infection) In response to the Td92 surface protein of the periodontal pathogen T.denticola, activated by cathepsin CTSG which leads to production and secretion of IL1A and pyroptosis of gingival fibroblasts.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 837 | ENSG00000196954 | CASP4 | P49662 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-117 | Pr-4 | 1 | 1 | 99 |
| R-1358 | Pr-4 | 1 | 1 | 6 |
| R-1592 | Pr-4 | 1 | 1 | 87 |
| R-1608 | Pr-4 | 1 | 1 | 8 |
| R-174 | Pr-4 | 1 | 1 | 9 |
| R-1829 | Pr-4 | 1 | 1 | 83 |
| R-2161 | Pr-4 | 1 | 1 | 71 |
| R-2477 | Pr-4 | 1 | 1 | 77 |
| R-259 | Pr-4 | 1 | 1 | 17 |
| R-298 | Pr-4 | 1 | 1 | 11 |
| R-3126 | Pr-4 | 1 | 1 | 11 |
| R-3345 | Pr-4 | 1 | 1 | 2 |
| R-3348 | Pr-4 | 1 | 1 | 104 |
| R-3377 | Pr-4 | 1 | 1 | 7 |
| R-359 | Pr-4 | 1 | 1 | 7 |
| R-371 | Pr-4 | 1 | 1 | 74 |
| R-397 | Pr-4 | 1 | 1 | 107 |
| R-419 | Pr-4 | 1 | 1 | 90 |
| R-737 | Pr-4 | 1 | 1 | 72 |