Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
CALD1 - caldesmon 1
Function
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 800 | ENSG00000122786 | CALD1 | Q05682 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1038 | Pr-3 | 1 | 1 | 2 |
| R-1161 | Pr-3 | 1 | 1 | 3 |
| R-118 | Pr-3 | 1 | 1 | 13 |
| R-1305 | Pr-3 | 1 | 1 | 16 |
| R-1465 | Pr-3 | 1 | 1 | 6 |
| R-1486 | Pr-3 | 1 | 1 | 6 |
| R-162 | Pr-3 | 1 | 1 | 8 |
| R-1646 | Pr-3 | 1 | 1 | 4 |
| R-1831 | Pr-3 | 1 | 1 | 10 |
| R-1905 | Pr-3 | 1 | 1 | 12 |
| R-1995 | Pr-3 | 1 | 1 | 9 |
| R-2080 | Pr-3 | 1 | 1 | 8 |
| R-2210 | Pr-3 | 1 | 1 | 2 |
| R-2279 | Pr-3 | 1 | 1 | 17 |
| R-2430 | Pr-3 | 1 | 1 | 9 |
| R-2587 | Pr-3 | 1 | 1 | 12 |
| R-2707 | Pr-3 | 1 | 1 | 10 |
| R-2758 | Pr-3 | 1 | 1 | 16 |
| R-2887 | Pr-3 | 1 | 1 | 14 |
| R-2965 | Pr-3 | 1 | 1 | 13 |
| R-2981 | Pr-20 | 1 | 1 | 5 |
| R-3054 | Pr-3 | 1 | 1 | 6 |
| R-3135 | Pr-3 | 1 | 1 | 15 |
| R-3549 | Pr-3 | 1 | 1 | 8 |
| R-3561 | Pr-3 | 1 | 1 | 3 |
| R-3570 | Pr-3 | 1 | 1 | 8 |
| R-358 | Pr-3 | 1 | 1 | 9 |
| R-378 | Pr-3 | 1 | 1 | 85 |
| R-510 | Pr-3 | 1 | 1 | 4 |
| R-578 | Pr-3 | 1 | 1 | 6 |
| R-700 | Pr-3 | 1 | 1 | 2 |