Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ARSB - arylsulfatase B
Function
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 411 | ENSG00000113273 | ARSB | P15848 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1085 | Pr-3 | 1 | 1 | 3 |
| R-1161 | Pr-3 | 1 | 1 | 3 |
| R-118 | Pr-3 | 1 | 1 | 13 |
| R-1465 | Pr-3 | 1 | 1 | 6 |
| R-162 | Pr-3 | 1 | 1 | 8 |
| R-1646 | Pr-3 | 1 | 1 | 4 |
| R-1753 | Pr-3 | 1 | 1 | 2 |
| R-179 | Pr-3 | 1 | 1 | 11 |
| R-1831 | Pr-3 | 1 | 1 | 10 |
| R-1995 | Pr-3 | 1 | 1 | 9 |
| R-2080 | Pr-3 | 1 | 1 | 8 |
| R-2210 | Pr-3 | 1 | 1 | 2 |
| R-2497 | Pr-3 | 1 | 1 | 7 |
| R-2587 | Pr-3 | 1 | 1 | 12 |
| R-2707 | Pr-3 | 1 | 1 | 10 |
| R-2758 | Pr-3 | 1 | 1 | 16 |
| R-2887 | Pr-3 | 1 | 1 | 14 |
| R-2965 | Pr-3 | 1 | 1 | 13 |
| R-3054 | Pr-3 | 1 | 1 | 6 |
| R-3135 | Pr-3 | 1 | 1 | 15 |
| R-3549 | Pr-3 | 1 | 1 | 8 |
| R-3561 | Pr-3 | 1 | 1 | 3 |
| R-3576 | Pr-3 | 1 | 1 | 4 |
| R-3580 | Pr-3 | 1 | 1 | 12 |
| R-378 | Pr-3 | 1 | 1 | 85 |
| R-420 | Pr-3 | 1 | 1 | 11 |
| R-578 | Pr-3 | 1 | 1 | 6 |
| R-700 | Pr-3 | 1 | 1 | 2 |
| R-998 | Pr-3 | 1 | 1 | 88 |