Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ARPC1B - actin related protein 2/3 complex subunit 1B
Function
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 10095 | ENSG00000130429 | ARPC1B | O15143 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-108 | Pr-7 | 1 | 1 | 9 |
| R-112 | Pr-7 | 1 | 1 | 20 |
| R-117 | Pr-4 | 1 | 1 | 99 |
| R-1518 | Pr-4 | 1 | 1 | 7 |
| R-158 | Pr-7 | 1 | 1 | 59 |
| R-1592 | Pr-4 | 1 | 1 | 87 |
| R-1608 | Pr-4 | 1 | 1 | 8 |
| R-1829 | Pr-4 | 1 | 1 | 83 |
| R-2123 | Pr-4 | 1 | 1 | 85 |
| R-2161 | Pr-4 | 1 | 1 | 71 |
| R-2305 | Pr-4 | 1 | 1 | 12 |
| R-232 | Pr-7 | 1 | 1 | 77 |
| R-2456 | Pr-4 | 1 | 1 | 3 |
| R-257 | Pr-7 | 1 | 1 | 56 |
| R-259 | Pr-4 | 1 | 1 | 17 |
| R-2767 | Pr-4 | 1 | 1 | 70 |
| R-2885 | Pr-4 | 1 | 1 | 81 |
| R-290 | Pr-7 | 1 | 1 | 68 |
| R-2943 | Pr-4 | 1 | 1 | 14 |
| R-298 | Pr-4 | 1 | 1 | 11 |
| R-3126 | Pr-4 | 1 | 1 | 11 |
| R-3345 | Pr-4 | 1 | 1 | 2 |
| R-3348 | Pr-4 | 1 | 1 | 104 |
| R-350 | Pr-7 | 1 | 1 | 95 |
| R-356 | Pr-7 | 1 | 1 | 57 |
| R-359 | Pr-4 | 1 | 1 | 7 |
| R-370 | Pr-7 | 1 | 1 | 30 |
| R-371 | Pr-4 | 1 | 1 | 74 |
| R-395 | Pr-7 | 1 | 1 | 44 |
| R-397 | Pr-4 | 1 | 1 | 107 |
| R-413 | Pr-7 | 1 | 1 | 23 |
| R-419 | Pr-4 | 1 | 1 | 90 |
| R-438 | Pr-7 | 1 | 1 | 44 |
| R-737 | Pr-4 | 1 | 1 | 72 |
| R-86 | Pr-7 | 1 | 1 | 62 |