Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ADM - adrenomedullin
Function
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 133 | ENSG00000148926 | ADM | P35318 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1018 | Pr-39 | 1 | 1 | 5 |
| R-1042 | Pr-6 | 1 | 1 | 5 |
| R-1129 | Pr-39 | 1 | 1 | 15 |
| R-1166 | Pr-39 | 1 | 1 | 12 |
| R-1185 | Pr-177 | 1 | 1 | 14 |
| R-121 | Pr-39 | 1 | 1 | 9 |
| R-1225 | Pr-39 | 1 | 1 | 24 |
| R-1253 | Pr-39 | 1 | 1 | 28 |
| R-1285 | Pr-177 | 1 | 1 | 5 |
| R-142 | Pr-6 | 1 | 1 | 8 |
| R-1470 | Pr-39 | 1 | 1 | 5 |
| R-1487 | Pr-6 | 1 | 1 | 11 |
| R-1490 | Pr-39 | 1 | 1 | 13 |
| R-1525 | Pr-6 | 1 | 1 | 11 |
| R-1597 | Pr-39 | 1 | 1 | 9 |
| R-1707 | Pr-39 | 1 | 1 | 14 |
| R-1790 | Pr-39 | 1 | 1 | 6 |
| R-1834 | Pr-6 | 1 | 1 | 8 |
| R-1936 | Pr-6 | 1 | 1 | 14 |
| R-1985 | Pr-6 | 1 | 1 | 23 |
| R-2002 | Pr-177 | 1 | 1 | 23 |
| R-2105 | Pr-39 | 1 | 1 | 32 |
| R-217 | Pr-6 | 1 | 1 | 11 |
| R-2195 | Pr-6 | 1 | 1 | 12 |
| R-2266 | Pr-6 | 1 | 1 | 5 |
| R-2289 | Pr-39 | 1 | 1 | 6 |
| R-2342 | Pr-6 | 1 | 1 | 6 |
| R-2362 | Pr-39 | 1 | 1 | 9 |
| R-2399 | Pr-20 | 1 | 1 | 12 |
| R-2480 | Pr-6 | 1 | 1 | 2 |
| R-2752 | Pr-6 | 1 | 1 | 13 |
| R-2845 | Pr-39 | 1 | 1 | 10 |
| R-2914 | Pr-39 | 1 | 1 | 14 |
| R-2929 | Pr-39 | 1 | 1 | 22 |
| R-2964 | Pr-39 | 1 | 1 | 26 |
| R-3056 | Pr-39 | 1 | 1 | 22 |
| R-3092 | Pr-6 | 1 | 1 | 3 |
| R-3106 | Pr-177 | 1 | 1 | 10 |
| R-3166 | Pr-6 | 1 | 1 | 11 |
| R-3292 | Pr-39 | 1 | 1 | 4 |
| R-3493 | Pr-6 | 1 | 1 | 3 |
| R-3542 | Pr-39 | 1 | 1 | 7 |
| R-3550 | Pr-6 | 1 | 1 | 7 |
| R-3602 | Pr-177 | 1 | 1 | 17 |
| R-3683 | Pr-39 | 1 | 1 | 20 |
| R-379 | Pr-6 | 1 | 1 | 10 |
| R-426 | Pr-39 | 1 | 1 | 20 |
| R-450 | Pr-6 | 1 | 1 | 11 |
| R-629 | Pr-6 | 1 | 1 | 10 |
| R-649 | Pr-6 | 1 | 1 | 13 |
| R-670 | Pr-177 | 1 | 1 | 17 |
| R-671 | Pr-6 | 1 | 1 | 6 |
| R-702 | Pr-39 | 1 | 1 | 4 |
| R-704 | Pr-6 | 1 | 1 | 7 |
| R-851 | Pr-39 | 1 | 1 | 3 |
| R-873 | Pr-39 | 1 | 1 | 6 |
| R-892 | Pr-177 | 1 | 1 | 2 |
| R-974 | Pr-39 | 1 | 1 | 5 |