Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ADAMTS1 - ADAM metallopeptidase with thrombospondin type 1 motif 1
Function
Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 9510 | ENSG00000154734 | ADAMTS1 | Q9UHI8 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1046 | Pr-1 | 1 | 1 | 2 |
| R-1073 | Pr-1 | 1 | 1 | 4 |
| R-1133 | Pr-1 | 1 | 1 | 8 |
| R-1170 | Pr-1 | 1 | 1 | 4 |
| R-12 | Pr-1 | 1 | 1 | 14 |
| R-1495 | Pr-1 | 1 | 1 | 7 |
| R-1651 | Pr-1 | 1 | 1 | 3 |
| R-167 | Pr-1 | 1 | 1 | 10 |
| R-1818 | Pr-1 | 1 | 1 | 2 |
| R-1886 | Pr-1 | 1 | 1 | 5 |
| R-1912 | Pr-1 | 1 | 1 | 8 |
| R-2005 | Pr-1 | 1 | 1 | 13 |
| R-2053 | Pr-1 | 1 | 1 | 61 |
| R-2268 | Pr-1 | 1 | 1 | 5 |
| R-2309 | Pr-1 | 1 | 1 | 9 |
| R-2322 | Pr-1 | 1 | 1 | 6 |
| R-2364 | Pr-1 | 1 | 1 | 5 |
| R-2438 | Pr-1 | 1 | 1 | 14 |
| R-2543 | Pr-1 | 1 | 1 | 7 |
| R-2620 | Pr-1 | 1 | 1 | 3 |
| R-2705 | Pr-9 | 1 | 1 | 14 |
| R-2762 | Pr-1 | 1 | 1 | 15 |
| R-2811 | Pr-1 | 1 | 1 | 5 |
| R-2954 | Pr-1 | 1 | 1 | 14 |
| R-3016 | Pr-1 | 1 | 1 | 21 |
| R-3066 | Pr-1 | 1 | 1 | 6 |
| R-3107 | Pr-1 | 1 | 1 | 5 |
| R-3168 | Pr-1 | 1 | 1 | 5 |
| R-3264 | Pr-1 | 1 | 1 | 5 |
| R-3291 | Pr-1 | 1 | 1 | 5 |
| R-3379 | Pr-1 | 1 | 1 | 5 |
| R-3552 | Pr-1 | 1 | 1 | 6 |
| R-3563 | Pr-1 | 1 | 1 | 3 |
| R-3603 | Pr-9 | 1 | 1 | 34 |
| R-362 | Pr-1 | 1 | 1 | 8 |
| R-3781 | Pr-1 | 1 | 1 | 9 |
| R-385 | Pr-1 | 1 | 1 | 15 |
| R-582 | Pr-1 | 1 | 1 | 6 |
| R-632 | Pr-1 | 1 | 1 | 10 |
| R-646 | Pr-140 | 1 | 1 | 51 |
| R-683 | Pr-1 | 1 | 1 | 14 |
| R-856 | Pr-1 | 1 | 1 | 6 |
| R-980 | Pr-1 | 1 | 1 | 6 |