Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ABCA1 - ATP binding cassette subfamily A member 1
Function
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 19 | ENSG00000165029 | ABCA1 | O95477 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1129 | Pr-39 | 1 | 1 | 15 |
| R-1166 | Pr-39 | 1 | 1 | 12 |
| R-121 | Pr-39 | 1 | 1 | 9 |
| R-1225 | Pr-39 | 1 | 1 | 24 |
| R-1253 | Pr-39 | 1 | 1 | 28 |
| R-1285 | Pr-177 | 1 | 1 | 5 |
| R-1490 | Pr-39 | 1 | 1 | 13 |
| R-1597 | Pr-39 | 1 | 1 | 9 |
| R-1790 | Pr-39 | 1 | 1 | 6 |
| R-2105 | Pr-39 | 1 | 1 | 32 |
| R-2289 | Pr-39 | 1 | 1 | 6 |
| R-2399 | Pr-20 | 1 | 1 | 12 |
| R-2431 | Pr-12 | 1 | 1 | 72 |
| R-2690 | Pr-39 | 1 | 1 | 13 |
| R-2817 | Pr-39 | 1 | 1 | 10 |
| R-2830 | Pr-12 | 1 | 1 | 69 |
| R-2864 | Pr-12 | 1 | 1 | 62 |
| R-3106 | Pr-177 | 1 | 1 | 10 |
| R-3481 | Pr-12 | 1 | 1 | 45 |
| R-3604 | Pr-12 | 1 | 1 | 61 |
| R-3683 | Pr-39 | 1 | 1 | 20 |
| R-426 | Pr-39 | 1 | 1 | 20 |
| R-556 | Pr-39 | 1 | 1 | 6 |
| R-61 | Pr-12 | 1 | 1 | 55 |
| R-651 | Pr-12 | 1 | 1 | 76 |
| R-702 | Pr-39 | 1 | 1 | 4 |
| R-851 | Pr-39 | 1 | 1 | 3 |
| R-873 | Pr-39 | 1 | 1 | 6 |
| R-892 | Pr-177 | 1 | 1 | 2 |
| R-974 | Pr-39 | 1 | 1 | 5 |