Regulon – gbmMINER Portal

Regulon: R-823

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
14	0.566633	1	0	Pr-143

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
23161	ENSG00000071189	SNX13	A0A087WUZ7
9689	ENSG00000082153	BZW1	Q7L1Q6
3655	ENSG00000091409	ITGA6	P23229
5216	ENSG00000108518	PFN1	P07737
5878	ENSG00000108774	RAB5C	A0A024R1U4
3312	ENSG00000109971	HSPA8	A8K7Q2
55825	ENSG00000115425	PECR	Q9BY49
6272	ENSG00000134243	SORT1	Q99523
1973	ENSG00000161960	EIF4A1	P60842
5580	ENSG00000163932	PRKCD	Q05655
3766	ENSG00000177807	KCNJ10	P78508
9802	ENSG00000183283	DAZAP2	Q15038
8073	ENSG00000184007	PTP4A2	Q12974
4067	ENSG00000254087	LYN	P07948

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
MIDOSTAURIN	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	4	0
DASATINIB	ABL1	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	4	2
FORIGERIMOD	HSPA8	Protein	INHIBITOR	Heat shock cognate 71 kDa protein inhibitor	3	0
BOSUTINIB	ABL1	Small molecule	INHIBITOR	Bcr/Abl fusion protein	4	2
BAFETINIB	LYN	Small molecule	INHIBITOR	Tyrosine-protein kinase ABL inhibitor	2	0
SOTRASTAURIN	PRKD3	Small molecule	INHIBITOR	Protein kinase C (PKC) inhibitor	2	0
ILORASERTIB	PDGFRB	Small molecule	INHIBITOR	Serine/threonine-protein kinase Aurora inhibitor	2	0
JNJ-26483327	ERBB2	Small molecule	INHIBITOR	Tyrosine-protein kinase FYN inhibitor	1	0
UCN-01	CDK4	Small molecule	INHIBITOR	3-phosphoinositide dependent protein kinase-1 inhibitor	2	0
XL-228	ABL1	Small molecule	INHIBITOR	Tyrosine-protein kinase ABL inhibitor	1	0
FORIGERIMOD ACETATE	HSPA8	Protein	INHIBITOR	Heat shock cognate 71 kDa protein inhibitor	3	0
TOLIMIDONE	LYN	Small molecule	POSITIVE ALLOSTERIC MODULATOR	Tyrosine-protein kinase Lyn positive allosteric modulator	2	0
TG100-801	EPHB4	Small molecule	INHIBITOR	SRC inhibitor	2	0
DELCASERTIB	PRKCD	Protein	INHIBITOR	Protein kinase C delta inhibitor	2	0
GSK-690693	PRKACB	Small molecule	INHIBITOR	Protein kinase C (PKC) inhibitor	1	0
ENMD-981693	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	2	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-823

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs